DMSO is quite effective in reducing inflammation and preventing the formation of rheumatoid and so there could be a similar affect occurring with the tissue transformation caused by Dupuytren's. I have tried DSMO with my hands but did not get any relief.

With severe cases of juvenile rheumatoid arthritis the DMSO is injected into the affected joints for maximum affect. A lot of research was done over a period of decades by Dr. Stanley Jacobs at the Oregon Health Sciences University. The active ingredient is thought to be MSM which can be taken as a supplement, it does not penetrate the dermis the way DMSO does so the topical application should be more effective.