I was told it is not alcohol but liver problems, which of course may be caused by alcohol.

HI I'M 52 YEARS OLD AND HAVE DUPYTRENS, I HAD SURGERY 2 YEARS AGO AND REALLY MADE IT WORSE. I HAVE IT IN BOTH HANDS AND 1 FOOT. I DRANK ALOT 30 YEARS AGO WHEN IN THE SERVICE. BUT FOR THE PAST 30 YEARS I DRANK NO MORE THAN 2-3 BEERS DURING A 6 MONTH PERIOD.I REALLY DONT THINK AC CAUSED MINE. THE ONLY THING THAT HELPS ME IS VITAMIN E, I TAKE 400 IU PER DAY.

I'm sure that in some cases alcohol plays a part in the spread of the nodules associated with DC, however this would negate the fact that it is an hereditary disease. I personally do not drink excessively and take vitamin E but still developed Dupytrens Contracture and Plantar Fibromatosis at an early age (30). In addition it has continued to spread - I had to have 2 surgeries last year in order to remove the nodules in my feet.
Recently I heard of some work that was being done in Europe, which linked the disease to the DNA in the skin. They discovered by accident that if you remove skin in the affected area and replace it with fresh skin, there was no recurrence of the nodule - this was known as a "firebridge"
skin graft. Does anyonw else have further information on this technique?

I do not know if alcohol is involved. I never was a person who was a drinker nor really liked to drink but did drink socially in my 20's and more than several times got high after just a few drinks. Alcohol always had an effect on me that seemed quick, but it is hard to compare to others. I have wondered if it was inherited weak liver or maybe caused by getting sick drunk just two times in my 20's that changed something in my liver.

The protein issue is something I have wondered about because the liver makes protein from food intake and also converts proteins that we eat into amino acids then back to other proteins the body needs. It also converts proteins into other things. It is very complex and not well understood. Science says our bodies continuously have 3,500 enzyme processes going on at the same time.
The reason I mention protein is that the DC deposits are some form of abnormal protein (fibroblasts as they call them).
Anyine have any comments on protein or the liver.

Hi, Everyone seems to look on the consumption of alcohol as a prerequisite for getting DC. I first had DC symptons about 15 years ago. My alcohol consumption was then a few pints of beer a week, perhaps a glass or two of 'social' wine drinking. My first surgery on my left hand was 8 years ago, then on my right hand 5 years ago. These were essentially on my little fingers. In October 2003 I had second surgery to my right hand as the ring finger had started to curl as well. Now in February this year my left hand was operated on to address contracture in little amd ring fingers and large nodules on the palm. My condition is progressive and now a chord across the palm is strongly present and growing to my middle finger on my left hand and it has started to curl. I anticipate further surgery in about twelve months time.
Coincidental to these last two operations I was given a 60'th birthday present of a subscription to Wineshare. So I have a row of vines in France and have been down to pick the grapes and enjoy tasting, etc. But my consumption of wine has increased substantially. It started to increase about three to four years ago, and in retrospect I feel that taking up drinking was partly to help compensate for the anxiety and stress caused by my galloping DC. So for me, a higher alcohol consumption has followed my CD development. Perhaps there are others who have experienced this?
I have no family history of DC, nor of alcoholism.
Best to everyone,
Bob