Has anyone had any success with anything without surgery I had surgery on my left hand (fillet it) sucessful but very painfull and dibilitating. Now my right hand is under attack and I would like to think some inroads have been made.This may seem weird but it seemed to take off when I started the sugarbusters diet could there be a relationship.I heard that vitamin E might help.Will straping my hand at night or streching my fingers help or will it further exasorbate the problem,any help would be appreciated

I've yet to see a credible success story for vitamin e, potaba, alpha lipoic acid, verapamil, or any other non-surgical treatment other than needle aponevrotomy.

However, that doesn't mean that none of those substances could help. Some medical people seem to think that antioxidants should be effective, but there's just nothing conclusive. I've taken 400 IU of vitamin E daily for at least a couple of years - the disease still progresses. Of course, it might have progressed faster without the vitamin E. I recently increased to 1200 IU daily.

I can't find any definite answers on stretching or splinting, either. Some claim it's helped, others say it only makes things worse.

Please let somebody correct me if I am wrong.
As I understand it : a drug under development is designated 'orphan' drug if the 'disease' it is meant for occurs in less than 200 000 people in the usa.
In the case of cordase, the designation was given in '98 (cordiase has been under investigation since '95), so it doesnt say anything about the present state of the drug.
Presently, phase II is finished for cordiase.
I read that a phase III investigation can take 3 to 4 years, before production of the drug can be started up.
I hope I am wrong here, but we surely arent out of the woods yet :(