When my sister suggested this home remedy I was immediately skeptical, but she says her doctor recommended it:

Twice a day, rub the nodules with high potency Vitamin E oil. You can find it at drugstores and health food stores usually with the lotions. This is much stronger than pills. Get the strongest kind. You can find 28,000 IU's and I found one bottle with 70,000 IU's at a health food store. It's pretty greasy, but tends to soak in after about 10 minutes. DO NOT lick your fingers after putting it on or you may overdose on E!

Second remedy:
My research says collogen deposits occur from a imbalance of the collogen/collogenase reaction, usually resulting from a weakened liver. That's the theory anyway, as to why alcoholics have more trouble with Dupuytrens. So, I started taking the following supplements to strengthen my liver:

Alpha Lipoic Acid - 200 mgs
Coenzyme Q10 - 100-200 mgs
Milk Thistle 200-400 mgs

I've also cut down on drinking A LOT, and of course stopped taking Chondroiton-Glusosomine and avoid any lotions with collogen or aloe.

I wish I could have done each of these remedies one at a time for a more "scientific" survey of results, but frankly didn't have the patience for it. Don't know if one or more of these remedies are working but here's the punch line:

In the last month, my Dupuytren's nodule has shrunk to 50% of its original size! That really surprised and encouraged me. I will keep this forum updated with any further progress or relapse. Good luck.

Welcome back. I might give the mixture a try.

Kent,
Very interesting. Interest in vitamin E as a treatement for DC has waxed and waned for decades, apparently with no conclusive study either way.

I'd like to know the brand name of the Vitamin E you're using. I've never been able to find high-potency oil or cream. There are so many hucksters selling vitamins on the Web that a Google search is useless.

Gary, I can't agree with you there.
First of all, I suppose we are all in 'guessing games' here. If we would just sit back and wait until the FDA, or whatever organisation, would approve some new medication, this forum would have no reason to exist.
As to people reacting in different ways to some remedies, that is also valid for e.g. surgery. I know you are happy with the outcome of yours, but I am not so happy with mine.
Just as a reminder : my surgery went well, fingers absolutely straight even after 16 months, but surgery seems to have accelerated the DP in other parts of the hand and even more so in my other hand.
So, personally, I am going to apply vitamine E and also DMSO. Maybe it won't help, but as far as I can see, I don't have too worry too much about negative effects.
Btw, I intend to stop with the acupuncture treatment I was having, more about that in another posting.

One additional note.
I did change my diet at about the same time as my surgery. No red meat or fowl, only fish. No dairy products. No soda pop. Limited sugar intake. No alchoholic beverages(never used previously). No tobacco use (never used previously) All of this may or may not have had an influence on the temporary improvement of my DC. It would take a controlled study to evaluate this information.
Gary