I am starting this topic because Joe and John656 had mentioned that they will try Santyl. I think it might make sense to collect experience with Santyl and assess its effect, at least more anecdotes.
For those who are not familiar with Santyl: Abbott Laboratories started marketing Santyl in 2003 (there might have been someone else previously). Santyl is basically collagenase in a topical cream. Abott is using collagenase produced by BioSpecifics (and now probably by Auxilium). The cream also contains ingredients that are meant to help collagenase to get across the skin into the Dupuytren tissue. "This prescription ointment is indicated for debridement of chronic dermal ulcers and second and third degree burns." (http://www.biospace.com/news_story.aspx?...tityId=14254020).
While collagenase injections are aiming to break a cord, Santyl is speculated to be possibly able to reduce a nodule or cord or reduce its growth rate.
So far I haven't found any positive reports on Santyl and Dupuytren's contracture. It might well be that the announcement of Santyl was primarily a marketing effort. But maybe not enough people have tried it. There are also some posts on Santyl in this forum, click on Search, type in Santyl, and select "search in topics and answers".
By the way: We are not encouraging anyone to use Santyl. There is no indication that it works for Dupuytren's contracture and it is not approved by the FDA for this use. But if someone has experience with it, good or bad, it would be great it he/she would post it here.
I began using Santyl and DMSO combined several weeks ago, and within days saw an increased mobility and reduction in node size. I also have Lederhose, so the progress on my feet is most impressive. Not to say that any others would see same reaction to this combination, but my logic was that DMSO would carry the Collengenase into the affected area, much like recieving an injection. I am hoping to continue this for months. The charge for the Santyl was minimal, the DMSO is from any health food store, and relief to know that there IS something that can improve my situation is priceless
The only medication covered under my medical plan is the 250mg ointment, avialable with a prescription. I mix that, and a bit of MDSO nightly into the various nodes and have seen and felt dramatic results. I currently use a roll-on DMSO, but am going to pick up a petroleum based version and mix my own verison of this. I also found that most medical plans will allow about 4 tubes of Santyl for each 3 month period. My doctor wrote a year's prescription for this, and it is being filled without quesiton
I want to add a post from another thread because it really belongs here:
... He knows I have researched this, and Santyl does no harm to healthy tissue -- the only thing that might have happened is nothing. ... Dana
Sorry, but I have difficulties to believe this. How should a chemical be able to distinguish between "healthy" collagen and "sick" Dupuytren's collagen??
We had wonderful reports on topical Verapamil which then turned out as useless. Now it seesm to be Santyl's turn. I don't question Dana's improvements but if Santyl would work so well for everyone I am sure Joe and John would have reported it long ago.
Santyl is an enzyme that breaks down collegen. It does not distinguish between "good" and "bad" tissue and is applied topically to wounds to remove necrotic tissue and prevent gangrene. The manufacturer and the health care guidelines advice against using it on healthy skin.
That said there is no reason to believe that injecting the active substance into the hand is somehow safer than applying the same substance topically using DMSO. There have been Stage I, II, and III trials and when and if the finding are released to the general public we will know more about risks involved.
As with any treatment one needs to weight the probable benefits against the probable risks and make a case by case decision as to whether to proceed.
DMSO is not going to carry Santyl into the diseased tissue because neither DMSO nor Santyl "recognize' that tissue as a target in any way. The Santyl is going to go wherever DMSO happens to take it - around, or right through, the bad tissue and possibly right into your blood stream. This sounds dangerous to me.
Sorry you believe my post was a fake. I got the original idea from the wonderful data on your site, and thought I would supply back information others might find useful.. In addition to my hands, I have an inorperable tumor on the bottom of one foot ( as I have a clotting disorder they will not remove it) and I now have loose skin there, and for the first time in many years am beginning to see the outline of the side of my foot . I am careful to apply to only the affected areas, and also do not see the difference between injections and my approach. Both cause the eventual release of this medication into the system and the trials have shown no ill effects.
I will not post more t this site due to your attitude toward nonconventional approaches to healing, however I do wish you all well in your wait for a cure. Dana
Dana, if what you're saying is true, I still think it's risky. DMSO is a loose cannon - it will carry stuff anywhere, it doesn't "know" where to stop. I doubt that collagenase can be carried through the skin in this way, but if it can, there's no telling where it will end up and what it will do. Injection puts it right where the MD wants it to be - inside the bad tissue. DMSO could put it into your bloodstream and from there, anywhere in your body. Many structures in your body are made of collagen. Think long and hard about this - if it really worked, and was safe, Auxilium would be marketing Santyl for this purpose instead of spending millions getting the injectable form approved.