Sides effects of the injection vary. From xiaflex.com:

The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include:
• swelling of the injection site or the hand
• bruising or bleeding at the injection site
• pain or tenderness of the injection site or the hand
• swelling of the lymph nodes (glands) in the elbow or armpit
• itching
• breaks in the skin
• redness or warmth of the skin
• pain in the armpit

Of course, typically you would not expect to get all of the above. I myself had after the injection bruising, swelling of the hand, and some pain but just a little. I would say if you have a job that is not requiring heavy manual workload then there is a good chance that you can keep working. If you have to do heavy manual work then you would better plan for something else for that day and maybe reduced workload for the next two weeks. But there is also a chance that your husband won't experience any of the above side effects.

Wolfgang

It depends on how the procedure is done to a degree greater than I would have expected. When I first had Xiaflex injections in 2013 the doctor's practice was to wait a week before doing the release and this turned out to be a mistake as my hands became very swollen and so the skin tore and healing took a couple of weeks.

The second time I had the injections and at my request the release manipulation was done the very next day and the recovery time was a few days and much less swelling took place.

The third time the doctor did the injections again on the first day in the afternoon (as it was a 2.5 hour drive from my house to his office) and the following day in the morning he did a combination of manipulation and NA. As a general is used prior to the manipulation (and the Xiaflex injections for that matter), my hand was numb and so no issues with the use of NA on it.

I had NA only in 2007 (along with RT in Germany and the US) and Xiaflex (one vial) in 2013 followed by NA, and then Xiaflex (2 vials) followed by NA the day after the injections in July and November of 2013. The insurance company only allowed one vial during treatment which is why I needed to wait a couple months and then have the second vial of Xiaflex injected.

A representative from the company that sells Xiaflex in the USA was present to photography the combination of manipulation and NA on my hand as it was the first time this had been done to their knowledge.

Now nearly 4 years later my hand is in great shape with no contracture whatsoever and a great deal less pain after doing hand intensive tasks that involve tightly gripping something.

I used the services of Dr. Denkler in northern California just north of San Francisco and he is a certified hand surgeon who has extensive experience doing fasciectomies as well as the NA procedure and injecting Xiaflex. His experience and flexibility in approaching each individual's situation as needed is very rare in the medical community where standardized care is considered a virtue with no though as to its overall efficacy from patient to patient.

I interviewed and met with three other hand surgeons before finding Dr. Denkler in 2007 and I spoke with 3 other doctors that were much closer to my home and who were doing Xiaflex injections in 2013. None of them had the experience and overall knowledge of Dr. Denkler and I got some amazingly bad and inaccurate information during my interviews. including one surgeon, Dr. Ronald Gemberling in Campbell, CA who taught at Stanford and whose techniques were decades behind the times.