DMSO is quite effective in reducing inflammation and preventing the formation of rheumatoid and so there could be a similar affect occurring with the tissue transformation caused by Dupuytren's. I have tried DSMO with my hands but did not get any relief.

With severe cases of juvenile rheumatoid arthritis the DMSO is injected into the affected joints for maximum affect. A lot of research was done over a period of decades by Dr. Stanley Jacobs at the Oregon Health Sciences University. The active ingredient is thought to be MSM which can be taken as a supplement, it does not penetrate the dermis the way DMSO does so the topical application should be more effective.

There are multiple sources for the lotion that Dr Stanley Jacobs produces including his own website at:

https://jacoblab.com/OrderDMSODusaSAL.html

Another site with information on using DMSO is here: http://www.dupuytrens-contracture.com/du...tment-DMSO.html

Important to realize that DMSO carries whatever is on the skin into the blood stream and into cells so it is important to wash thoroughly before using to remove any contaminants that might be on your skin including other lotions.

The DMSO helps internal cellular repair while the urea helps soften the skin and keep it supple. Any lotion you use for your hands should have at least 10% urea as an ingredient to be effective.

Suffering from Epilepsy, the US Navy (before they discharged me after seventeen years) tried numerous medications for my seizure control. I had many different horrible reactions, and in 1995, they finally settled on phenobarbital, which had the effect of ending my seizures entirely, allowing me once again a more normal life . . . though not in the Navy. Now with Dupuytren's diagnosed about a year ago, I find that long-term usage of phenobarbital is implicated in starting or aggrevating Duyputren's. Curiously, the physicians involved in the DC care have not indicated that my phenobarbital perscription of fourteen years now could be implicated in my Dupuytren's.

Any information on this? I am about at the end of the line on seizure control besides phenobarbital; this is quite ironic: I can go without seizures or I can have use of my hands. (Typing this has been a real chore, lemme tell ya . . . and it plays havoc with my current job as an editor for a publishing company . . .)

@nurse1:

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Is Dupuytren's connected to seizures because of the drugs used to treat epilepsy or because of epilepsy itself? I did not have Dupuytren's until 10 years after I started having petit mal & a few partial complex seizures that were sudden onset in my late 30's. No trauma of any kind. Just lots of stress. I worked for 25 Anesthesiologists in a very busy OR. The more stress, the more frequent the seizures. I just had surgery of my R. index finger that was bent almost to my palm, but is straight now. I had the surgery 1 week ago, so still have stitches & working on bending. Still swollen, but it will get there.