Known side effects of collagenase (Xiaflex) injection to treat Dupuytren's contracture

 

For the time being known side effects are from the trials that were performed to get FDA approval, e.g.

LC Hurst et al. "Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture" New England Journal of Medicine 361 (2009) p 968-979. abstract. "The most commonly reported adverse events were localized swelling, pain, bruising, pruritus, and transient regional lymph-node enlargement and tenderness. Three treatment-related serious adverse events were reported: two tendon ruptures and one case of complex regional pain syndrome. No significant changes in flexion or grip strength, no systemic allergic reactions, and no nerve injuries were observed."

For further information on side effects of the injection of Xiaflex see the safety information on the Xiaflex website, the Xiaflex medication guide or drugs.com and drugwatch .

 

 

 

Page last modified: 04/01/2010