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04/19/2007 18:30
yankee21 
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04/19/2007 18:30
yankee21
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collagenase
Any new ,news on collagenase??
Anybody that was in the phaseIII trials willing to relate their experiences?
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05/09/2007 00:29
bstenman 
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05/09/2007 00:29
bstenman
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Re: collagenase
I spoke with the people at Stanford Medical that have been involved in the phase I and II trials. I was told that due to problems with production of the necessary quantity and quality of product for the trials that Phase III would not commence for two years.
As the company licensed to produce the collagenase enzyme product has had two subcontractors fail and is now in the process of building a new facility to be able to produce it internally, the two year estimate by the people at Stanford seems optimistic. Once trials begin (and they will be selecting people that did not make the cut for the Phase I and Phase II trials) it will be another year or more before there is FDA approval and doctors able to use it for the general public.
The treatment is a good alternative to dissolving damaged tissue and an alternative to NA or hand surgery. It will not prevent the disease or prevent it from spreading from one part of the hand as the injections are local in terms of the tissue area being treated.
I still view NAC supplements and radiotherapy as the best ways (based on current information) to prevent further progression of the disease. Time will tell.
Bruce
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05/09/2007 04:47
Mark_D 
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05/09/2007 04:47
Mark_D
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Re: collagenase
Bruce:
Depressing, but thanks for the update.
Mark
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05/09/2007 15:18
bstenman
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05/09/2007 15:18
bstenman
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Re: collagenase
Stonybrook is one of 3 locations in the USA that conducted Phase II trials and that are to be doing Phase III trials in order for Auxilium to get FDA approval to sell the product. That only one location and a total of 54 people were treated shows the present inability of Auxilium Pharmaceuticals to produce the enzyme in quantity.
This "trail" was done to prop up the stock price of Auxilium Pharmaceuticals. Best case I would expect the enzyme to be available some time in 2010. How fast the medical community starts to use it when it does become available is anyone's guess as well. The Dr. Denkler's of the world will be among the early adopters of this treatment which is really an alternative to NA.
At least the hand surgeons in the USA are usually plastic surgeons who are already injecting botox into their patients' faces, so psychologically they should be receptive to injecting the enzyme product into their patients' hands. Although it was after 7 years of trials with monkeys that botox was used on humans, and another 10 years before it was actively used by plastic surgeons.
Some day this enzyme will be a viable option but for the present time, i.e. the next 3-5 years, anyone with DC will need to avail themselves of other treatments.
Bruce
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05/10/2007 17:21
Fonznot registered
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05/10/2007 17:21
Fonznot registered
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Re: collagenase
 I'm a DP-patient from Belgium and pleased to finf out that in the States at least someone is doing an effort to find another therapy than churgery and NA. I am 48 years old and have had several times an intervention with the needle. But 2 years ago I was obliged to have churgery on my right hand. This hand is doing well but my left hand is getting worse. So I hope that within a few years there will be an alternative solution. On the other way, I think that a lot of churgians rather like to handle their scalpel than to give an injection (cheaper treatment). Anyway many thanks for the interesting info on this forum. I will certainly come back later for following up the developments in the States. Kind regards.
Fonz - Zemst - Belgium
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05/10/2007 21:04
Randy_H
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05/10/2007 21:04
Randy_H
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Pushing the Envelope
Fonz:
Thanks for stopping by.
Assuming you are referring to Collegenase as "another therapy", I think we should all agree that adding to our treatment options is going to be good. But you should know that Collegenase injections are not all that different from NA. They do almost *exactly* the same thing with the same effect. Now, if later it turns out that Collegenase can be injected directly into new nodules and effectively kill them, well that will be a neat trick. *Then* we will have something.
None doing the research has proposed this. However, it makes perfect sense to me. First it needs to get FDA approval for desolving just a portion of a Dups cord. After that it may be used "off label" *directly* into a nodule by brave and experimenting CHS who wants to push the envelope. I'll bet Denkler would be up for that, and I have a nodule or two for him to try this on :)
What do you say Dr. Keith?
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05/10/2007 23:18
Mark_D
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05/10/2007 23:18
Mark_D
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Re: collagenase & Dr. Denkler
Randy:
I agree that Keith Denkler will probably be among those pushing the envelope.
You've just got to love that guy.
I sure do!
Mark
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