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Dupyutren's and Risk of Peyronie's?
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07/20/20 03:00
Jaykson2 
07/20/20 03:00
Jaykson2 
Dupyutren's and Risk of Peyronie's?

I was reading that there is a possible link between Dupyutren's and Peyronies and was wondering if anyone knew how much more at risk those with Dupyutren's are of getting Peyronie's? Are there any statistics about the percentage of men with Peyronie's end up with Peyronie's? I'm trying to figure out if it is a casual link between the two or if it is essentially the same type of wound healing disorder meaning I would be very likely to get it if I ever had any microtrauma to the penis. I have found statistics for the percentage of men with Peyronie's have Dupyutrens but not the other way around.

Edited 07/20/20 03:02

07/20/20 08:54
wach 

Administrator

07/20/20 08:54
wach 

Administrator

Re: Dupyutren's and Risk of Peyronie's?

A link between Dupuytren's and Peyronie's may or may not exist https://www.dupuytren-online.info/IPP_and_others.html . A patient survey by the International Dupuytren Society in 2015 https://www.dupuytren-online.info/patient_survey.html did not show any conncection, different to Ledderhose which seems to be well connected with Dupuytren's.

Wolfgang

07/20/20 10:39
spanishbuddha 

Administrator

07/20/20 10:39
spanishbuddha 

Administrator

Re: Dupyutren's and Risk of Peyronie's?

A quick search suggests that it is more than just a possible statistical link but a causal link too. If we characterise these conditions as variants of an underlying fibrosis disorder then you would expect it to manifest in different ways. First two papers in my search were https://www.auajournals.org/doi/abs/10.1...%2817%2952751-2 and https://www.nature.com/articles/ijir201118 so there may be others. The DRG has a paper that confirms a common genetic base https://dupuytrens.org/similar-genes-fou...-and-peyronies/ But none of these answer the question will an individual with one manifestation also experience it in another way.

07/20/20 17:24
wach 

Administrator

07/20/20 17:24
wach 

Administrator

Re: Dupyutren's and Risk of Peyronie's?

I am sorry but I don't find those two papers convincing. The first one has a very small sample of just 9 patients, which makes it statistically irrelevant. The second one already presumes a connection between both diseases ("Peyronie's disease (PD) is known to be associated with Dupuytren's disease (DD) since 1828.") and finds that 22% of the patients with PD are also suffering from DD. Depending on the age distribution this might just be "normal" and not excessively much. E.g. in The Netherlands, the overall prevalence of Dupuytren's is 22 % https://pubmed.ncbi.nlm.nih.gov/23897337...to%2080%20years .

In the patient survey, as presented at the Groningen conference in 2015, more than 2,000 patients with DD participated. 9.5 % of the patients with DD also suffered from PD. The survey used the reported Age of Onset (AO) as figure of merit and found that having also PD did not make any difference in the age of onset of DD.
Without PD AO = 44.9 with PD AO = 46.5
That's quite different e.g. to Ledderhose (LD) which seems to be strongly connected with DD
Without LD AO = 49.2 with LD AO = 43.9

That means that patients suffering from both, DD and LD, experience a much earlier onset of Dupuytren's while suffering also from PD doesn't seem to make any difference. From this I would suspect that the link between DD and PD, if there is any, is only a weak one.

Wolfgang

spanishbuddha:
A quick search suggests that it is more than just a possible statistical link but a causal link too. If we characterise these conditions as variants of an underlying fibrosis disorder then you would expect it to manifest in different ways. First two papers in my search were https://www.auajournals.org/doi/abs/10.1...%2817%2952751-2 and https://www.nature.com/articles/ijir201118 so there may be others. The DRG has a paper that confirms a common genetic base https://dupuytrens.org/similar-genes-fou...-and-peyronies/ But none of these answer the question will an individual with one manifestation also experience it in another way.


Edited 07/21/20 06:50

07/21/20 00:56
Jaykson2 
07/21/20 00:56
Jaykson2 
Re: Dupyutren's and Risk of Peyronie's?

That is interesting that only 9.5 percent of patients with DD also had PD. I have read that 4-13% of men in general have PD. Why do you think so many websites/doctors talk about there being an association between the two when it might be within the same range as people without the other condition?

07/22/20 02:07
Jaykson2 
07/22/20 02:07
Jaykson2 
Re: Dupyutren's and Risk of Peyronie's?

Wolfgang,

Do you have a link for the study showing that 9.5% of people with DD had PD from Groningen? I would be interested in reading more about that.

07/22/20 10:22
wach 

Administrator

07/22/20 10:22
wach 

Administrator

Re: Dupyutren's and Risk of Peyronie's?

The program of the Groningen conference is on
https://dupuytrensymposium.org/scientific-program-groningen/

Most papers can be viewed there. The Dupuytren survey is in Session1. Click on "video" to watch the presentation.

The survey has been published in printed form as part of the book Werker P., Dias J., Eaton C., Reichert B., Wach W. (eds) "Dupuytren Disease and Related Diseases - The Cutting Edge"
https://link.springer.com/chapter/10.100...3-319-32199-8_5 . But be warned: this survey did not address PD beyond asking whether participants suffered from it. The focus is on Dupuytren's.

Wolfgang

Jaykson2:
Wolfgang,

Do you have a link for the study showing that 9.5% of people with DD had PD from Groningen? I would be interested in reading more about that.


Edited 07/22/20 10:24

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