Hi everyone! It has been well established in research that Dupuytren Disease is associated with a decreased BMI. Does anyone have any thoughts and/or knowledge about the relationship between eating disorders and Dupuytren Disease? Thanks!
"In recent years, however, an inverse association between a high BMI and the risk of DD have been reported in several studies indicating a possible protective factor linked to the fat tissue."
Rydberg, M., Zimmerman, M., Löfgren, J.P., Gottsäter, A., Nilsson, P.M., Melander, O. & Dahlin, L.B. 2021, "Metabolic factors and the risk of Dupuytren's disease: data from 30,000 individuals followed for over 20 years", Scientific reports, vol. 11, no. 1, pp. 14669-14669.
Rebecca :) Diagnosed at 19/Female/Family History of Dupuytren
Hi, it has been well established in research and has been supported by the Dupuytren Research group (see their blog).
1) Burkard, T., Lane, J., Holmberg, D., Burden, A.M. & Furniss, D. 2021, "POS1383 THE ASSOCIATION BETWEEN BARIATRIC SURGERY AND DUPUYTREN DISEASE: A COHORT STUDY FROM SWEDISH NATIONWIDE HEALTHCARE REGISTRIES", Annals of the rheumatic diseases, vol. 80, no. Suppl 1, pp. 974-975. 2) Gudmundsson, K.G., Arngrı́msson, R., Sigfússon, N., Björnsson, Á. & Jónsson, T. 2000, "Epidemiology of Dupuytren's disease: Clinical, serological, and social assessment. The Reykjavik Study", Journal of clinical epidemiology, vol. 53, no. 3, pp. 291-296. 3) Hacquebord, J.H., Chiu, V.Y. & Harness, N.G. 2017, "The Risk of Dupuytren Diagnosis in Obese Individuals", The Journal of hand surgery (American ed.), vol. 42, no. 3, pp. 149-155. 4) Major, M., Freund, M.K., Burch, K.S., Mancuso, N., Ng, M., Furniss, D., Pasaniuc, B. & Ophoff, R.A. 2019, "Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI", Genetic epidemiology, vol. 43, no. 6, pp. 629-645. 5) Rydberg, M., Zimmerman, M., Löfgren, J.P., Gottsäter, A., Nilsson, P.M., Melander, O. & Dahlin, L.B. 2021, "Metabolic factors and the risk of Dupuytren's disease: data from 30,000 individuals followed for over 20 years", Scientific reports, vol. 11, no. 1, pp. 14669-14669.
that's a good list, thsnk you! I did not want to question the findings about BMI, I just believe that there is no immediate/strong link between developing Dupuytren's and having a low BMI. A low BMI will increase the risk to develop DD but a moderate or above moderate BMI won't protect from getting Dupuytren's. Only really obese people seem to have a somewhat lower risk. The study of 2021 by Rdyberg et al. finds
"No significant associations were found between ... overweight, and incident DD, neither among men nor women". A lower risk was found only for obese people: "obese men had lower risk of DD compared to men with normal weight in the adjusted regression model, although the same results could not be convincingly shown among women."
Interestingly, the authors find that diabetes and heavy alcohol consumption are strongly related with the risk of developing Dupuytren's. Even relatively low amounts of alcohol consumption seem to increase this risk: "already a somewhat moderate alcohol consumption (1–2 standard drinks per day), well below the definition of low-risk consumption in some countries, is associated with an increased risk of DD."
If you want to reduce your risk for developing DD, a high BMI is probably not the way to go because this includes other risks, but not drinking alcohol seems to be relatively effective (and will help avoiding other diseases).