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Has Anyone Tried an Autoimmune Diet?
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12/16/18 15:39
GailSusan 
12/16/18 15:39
GailSusan 
Has Anyone Tried an Autoimmune Diet?

I’ve been reading about people whose multiple sclerosis and arthritis were put in remission thanks to anti-inflammatory, gluten free, and dairy free diets. I had a friend who was supposed to go on Humira for her arthritis and has been able to keep her RA under control with her diet. Humira has been shown as a promising drug for DC, so it made me wonder if diet can help DC.

I’m going to give it a try not so much for DC, but for my arthritis and general health. Just thought I’d see if anyone else has tried this and if it has any impact on DC?

12/16/18 20:13
mikes 
12/16/18 20:13
mikes 
Re: Has Anyone Tried an Autoimmune Diet?

I can tell you that my sister-in-law took Humira for fibromyalgia, which caused severe side affects and from which she had a hard time disassociating herself (dependency). So, I'd be careful...... Just my two cents

12/17/18 09:11
wach 

Administrator

12/17/18 09:11
wach 

Administrator

Re: Has Anyone Tried an Autoimmune Diet?

That - unfortunately - might be somewhat misleading. There is a trial ongoing testing anti-TNF for treating Dupuytren's https://clinicaltrials.gov/ct2/show/NCT03180957 but side-effects may be severe (as for adalimumab) and whether it helps for Dupuytren's is still unclear. Therefore, for the time being, THERE IS NO REASON FOR RECOMMENDING HUMIRA FOR DUPUYTREN'S. I would stay away from it.

Wolfgang

GailSusan:
... Humira has been shown as a promising drug for DC, so it made me wonder if diet can help DC.
...

12/17/18 09:41
Prof.Seegenschmiedt 
12/17/18 09:41
Prof.Seegenschmiedt 

Re: Has Anyone Tried an Autoimmune Diet?

wach:
That - unfortunately - might be somewhat misleading. There is a trial ongoing testing anti-TNF for treating Dupuytren's https://clinicaltrials.gov/ct2/show/NCT03180957 but side-effects may be severe (as for adalimumab) and whether it helps for Dupuytren's is still unclear. Therefore, for the time being, THERE IS NO REASON FOR RECOMMENDING HUMIRA FOR DUPUYTREN'S. I would stay away from it.

Wolfgang
GailSusan:
... Humira has been shown as a promising drug for DC, so it made me wonder if diet can help DC.
...


The clinical trial cited by Wolfgang https://clinicaltrials.gov/ct2/show/NCT03180957 has tested patients with advanced stages of Dupuytren Disease, who already need to undergo open hand surgery ! Prior to the planned operation the drug adalimumab (Humira (R)) was injected into one affected nodule, which was surgically removed 14 days after the injection. Since the trial is randomized the other treatment arm consists of pure saline injection into the affected nodule. The potentially effective dose of the drug which will be injected has not been established yet, thus a dose escalation was planned in the treatment arm!

The interim-results of this ongoing study have been published in July 2018 https://www.ncbi.nlm.nih.gov/pubmed/29983350?dopt=Abstract.

In the second part of the study the injection of adalimumab (Humira (R)) in early stages of Dupuytren Disease is tested. Dupuytren Disease with multiple nodules and cords is not addressed in this ongoing study.

So far, overall conclusion - like Wolfgang stated - NO RECOMMENDATION as a DIET for early or late stages of Dupuytren Disease!

Edited 12/17/18 10:24

12/17/18 15:32
GailSusan 
12/17/18 15:32
GailSusan 
Re: Has Anyone Tried an Autoimmune Diet?

I personally would never take Humira and I realize this drug is still in clinical trials for this purpose. It’s a drug with far reaching and severe side effects.

I also realize that a change in diet has no proven benefits. I’m just wondering if anyone has tried an anti-inflammatory diet and if they noticed any change in their Dupuytren’s.

12/18/18 00:20
Lizibet 
12/18/18 00:20
Lizibet 

Re: Has Anyone Tried an Autoimmune Diet?

Hi Gail Susan & others -

I followed the Swank diet pretty faithfully for almost 4 years (I have MS, diagnosed 1999) and I can honestly say that all it did for me was make me neurotic about food/eating. Meanwhile, my disability level went from EDSS 2 to 6 (a BIG change) and I went from walking okay with some balance issues to needing bilateral support or a walker all the time (wheelchair sometimes), and racked up major cognitive and other functional deficits as well. Diet may make a difference, but when I quit Swank, I didn't get any worse, and I was LOTS happier, and a lot less stressed. And less stress is important with any illness with an autoimmune component.

That said, there are things we can consume that have known anti-inflammatory properties, and those can be helpful - or at least not harmful - as part of overall eating.

For me, I think the real key is to eat a sensible, well-balanced diet. Get the "five (or more) a day" of the fruits and veggies, avoid too much fat, and REALLY avoid the processed junk...

A comment about the "-mab" drugs that are coming out for various conditions (That is, prescription drugs that have generic names that end with the last letters -mab): These extremely expensive drugs are generally various forms of humanized recombinant monoclonal antibodies -- that is, they are designed to interact with and direct a patient's immune cells. Many carry a "black box" warning that they can cause death from the human equivalent of "mad cow" -- they can cause progressive multifocal leukoencephalopathy (PML) - a fatal viral infection of the brain. It's worth looking CLOSELY at whether inconvenient symptoms are worth tens of thousands of dollars per year and a chance of death, in my humble opinion.

12/18/18 14:43
GailSusan 
12/18/18 14:43
GailSusan 
Re: Has Anyone Tried an Autoimmune Diet?

Thank you! I’ve been looking at the Wahl’s Protocol given Dr. Wahl’s success with her own MS. I’m sorry you are dealing with this debilitating condition and that a diet solution didn’t work for you. It’s helpful to hear from others to see what’s worked and what hasn’t.

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Dupuytren   dopt=Abstract   sister-in-law   anti-inflammatory   well-balanced   adalimumab   leukoencephalopathy   side-effects   interim-results   Autoimmune   clinicaltrials   fibromyalgia   unfortunately   Dupuytren’s   disassociating   debilitating   RECOMMENDING   prescription   RECOMMENDATION   NCT03180957