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Lack of sunlight and auto immune diseases
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11/06/10 02:34
jimh 
11/06/10 02:34
jimh 
Re: Lack of sunlight and auto immune diseases

Wolfgang, as a software engineer I'm very familiar with the term "vaporware".
Nothing is real until you can buy it.

Even if a specific gene is ultimately dentified, that isn't likely to result in an effective treatment within my lifetime.

11/21/10 18:54
JoanneH 
11/21/10 18:54
JoanneH 
Re: Lack of sunlight and auto immune diseases

Hi Wolfgang and Jim, I looked for and found the paper that Jim mentioned on the Vit D3 therapy used on the woman with the large Desmoid tumor. The similarities between Dupuytrens and these tumors is pretty striking. It's an interesting if somewhat technical read. It also mentions the history of successful use of Vit D3 in treating other cancer growths, which I know Wolfgang was interested in finding documentation for. Here's the link:
http://jjco.oxfordjournals.org/content/34/8/472.full

Also below is another very good article, this one from CNN's Dr.Sanja Gupta, about the importance of Vitamin D in preventing the onset of genetic diseases, especially auto-immune diseases.
(My link had a flaw so the kind poster below fixed it) Thanks!

Edited 04/14/11 18:08

12/17/10 19:53
David26

not registered

12/17/10 19:53
David26

not registered

Re: Lack of sunlight and auto immune diseases

correcting your link from above, I personally think the inherited component is the biggest reason people get DD but the auto-immune issue may play a role. Not much is known for sure.

http://pagingdrgupta.blogs.cnn.com/2010/...?iref=allsearch

Edited 12/18/10 04:16

01/02/11 19:40
JoanneH 
01/02/11 19:40
JoanneH 
Re: Lack of sunlight and auto immune diseases

Thanks for fixing that link! I agree that heredity plays a huge role in DD, as it does in many diseases, and most auto-immune diseases do run in families. They aren't mutually exclusive. But the great thing is that there are other trigger factors that determine if you get the disease and/or get it early in life. And these trigger factors are often things within our control. That is the message we should be getting from this Vitamin D news. Sunlight is not the enemy that we have assumed it is for the past 50 years. In moderation, it is a vital contributor to our functioning biology.

01/13/11 22:05
bstenman 
01/13/11 22:05
bstenman 
Re: Lack of sunlight and auto immune diseases

There is a good deal of recently published research on effect of vitamin D deficiency and incidence of heart disease and cancer. The recommended daily allowance was recently doubled by the Feds. So regardless of the possible benefits with regard to Dupuytren's the additional vitamin D is going to likely extend ones life.

People has differing capabilities to produce vitamin D with their bodies as well as the environmental factors and the quality of their food. With factory farming many trace elements are no longer provided by the food we eat and need to be supplemented.

I would appreciate links or information on published research that demonstrates that Dupuytren's is an autoimmune disorder. I have come across nothing along these lines and would like very much to review what has been found by others.

The Mayo Clinic is not a credible source for medical information in my own experience. The misinformation they publish on their website for the public is nearly criminal. Some may have read this bit from the Mayo Clinic website:

"Doctors don't know what causes Dupuytren's contracture. Some researchers have speculated that it may be associated with an autoimmune reaction, where a person's immune system attacks its own body tissues."

Saying that some unidentified researchers have "speculated" that Dupuytren's "may" be "associated" is not saying anything factual at all. And repeating this misinformation on this website give this unsupported statement credence that it does not merit in the least.

Unfortunately with the internet, bad information gets parroted about with one website stealing comments from another as with the ohiohealth.com website that grabbed the mayoclinic.com website text and repeated it verbatim. Lots of lazy and untrained people putting out a lot of misinformation on public websites and it is taking longer and longer to sift through all the detritus one finds while trying to find a kernel of truth.

01/13/11 22:56
bstenman 
01/13/11 22:56
bstenman 
Re: Lack of sunlight and auto immune diseases

There is some questionable science happening with regard to Dupuytren's being an autoimmune disorder. The most recent published research from 2007 was a study of 4,866 Danish CSCR carriers over 71,230 person-years (1980 through 2004) for autoimmune diseases recorded in the Danish Hospital Discharge Register. "The overall risk of any autoimmune disease among CSCR carriers was inconspicuous (SIR 1.2 [95% CI 0.95–1.5]; n = 74 cases observed versus 61.3 expected)"

Danes has a whole have the highest incidence of Duputrene's among the population of any country but only 74 cases showed any autoimmune possibility and most of the 74 showed juvenile rheumatoid arthritis and not Dupuytren's. Among a sample group of 4,866 one would expect there to be more than 400 individuals with Dupuytren's or at least 5x as many as were found.

"In a Norwegian study of 15,950 citizens, DD was present in 10.5% of men and in 3.2% of women (3). In a large 1962 review of published figures, P. F. Early arrayed the countries of European stock in order of incidence of DD: Denmark, Australia, New Zealand, Canada, United Kingdom, Germany, and the United States." If you cannot find a conclusive link with a massive study of Danes it is probable that the link does not exist or is not causal in nature.

So the numbers do not add up and are not even close to showing Dupuytren's to be an autoimmune disorder though these conjectures in the medical publications go back at least as far as 1963. In more than 45 years this postulation has not advanced one bit, even with all the biotechnology that has become available.

01/17/11 17:56
averageanne 
01/17/11 17:56
averageanne 
Re: Lack of sunlight and auto immune diseases

Keeping Dupuytrens at bay at present with stretching of afflicted finger. Disease started with a bad fall on my hand.

I was very low on Vit D a year ago and am now up to normal on the low side. To get to this level I have been taking 4000 units of D3 a day.

A simple blood test can tell you if you are low on the Vitamin. I will have another test in the Spring. I have always lived in the north: Northern Europe and North America.

Anything is worth a try.

01/17/11 23:17
cindy850 
01/17/11 23:17
cindy850 
Re: Lack of sunlight and auto immune diseases

Just curious since everybody is talking about vitamin d - i was wondering the best way to get tested because 2 years ago my number on my blood test was 11 and so i started to take 1000 i.u. and still do. My question is the doctors want you to test while you are taking d but i think you should be off of it for a week to get a correct reading. What do you think?

Edited 01/17/11 23:18

01/23/11 18:24
JoanneH 
01/23/11 18:24
JoanneH 
Re: Lack of sunlight and auto immune diseases

Whether or not Dupuytrens is or isn't auto-immune related is not that important. Keeping tabs on your Vit D levels is important for reducing risk of many diseases, whether auto-immune or not. As far as the question about testing your D levels, I don't think there is any reason to go off of it before your test unless you are just curious to see how low your natural level goes - the idea is to build up to a therapeutic level which I've heard is between 50-70. Not easy to do if you live in the north. A level of 11 is very low and I would think you might want to raise your IU's for a while til you get your level higher.
Thanks for keeping us posted - Would love to hear more feedback on what people find when they get their Vit D level tests back and if they notice any difference as their levels rise.

04/11/11 22:58
JoanneH 
04/11/11 22:58
JoanneH 
Re: Lack of sunlight and auto immune diseases

Just came across some interesting info about DC on a Diabetes site. It looks at Dupuytrens from a little different angle, namely from an insulin resistance/high blood glucose angle. They recommend looking at Vitamin deficiencies as possible cause and particularly Vitamin D as well as B Vitamins and minerals especially Magnesium, Zinc and Calcium to help level out blood glucose levels.

http://www.diabetesnet.com/about-diabete...ens-contracture

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