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My DC, Topical Verapamil, Genetic Clues and Questions
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05/21/19 01:59
Krystyn 
05/21/19 01:59
Krystyn 
My DC, Topical Verapamil, Genetic Clues and Questions

So I have DC only on my right hand and my grandmother on my mother's side had it as well. I also have some Finnish heritage. I have had plantar faciaitis which I now realize were some nodules that went away on my right foot. I also have would healing issues and slight keloid scarring. I also have a history of Bipolar Disorder in myself and my family on my mother's side. We also have high blood pressure and very early heart disease.

My DC started when I was about 25 and stopped progressing when I went on disability for my bipolar and stopped using computers all day and also change to a healthier lifestyle. Now it flares and is sometimes tighter but I just have the single chord and nodule.

12 years ago I had my genetic run by 23andme and went on a binge of learning about how my genes might be causing a myriad of issues we have. One gene that stood out was a Voltage Gated Calcium Ion Channel gene called CACNA1C. I have the gene changes in that gene that predispose me to Bipolar Disorder and it fact it is the single strongest gene change that is associated with Bipolar however it is only in 10% of European Caucasians. In the past they have used Calcium Channel Blockers to try and treat Bipolar but they have a hard time getting into the brain so they gave up (but now there is renewed interest).

These same calcium channels also affect fibroblasts and collagen, which is why the thought verapamil would help with DC. However, since there might be several different causes of DC, without knowing if you have these calcium channel gene changes you will not know if it will work, and it most likely will not. So that is just me thinking.

To me it is interesting that I have it on my right hand since I worked as a network engineer and used that had for my mouse. Mice can let off a lot of EMFs and EMFs are known to affect calcium channel signalling. I believe this is what causes the oxidative stress that leads to fibroblast changes.

I have attached an image of my hand.

That is the story, and now here are my questions:

1) I have no idea how much of the gel to use on my hand. Anyone use it before?
2) Anyone here have mood disorders in their family as well?
3) Anyone have their genetics from 23andme?

Thanks!

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05/21/19 08:26
spanishbuddha 

Administrator

05/21/19 08:26
spanishbuddha 

Administrator

Re: My DC, Topical Verapamil, Genetic Clues and Questions

Did you read this thread https://www.dupuytren-online.info/Forum_...il-1_178_1.html as one example of using Verapamil? There are others. Your cord looks as if it could be treated with NA or Xiaflex to my layman’s eye, what does a hand surgeon say? You could pursue one of those options and line up RT as potential follow up if there are signs of ongoing progression after that.

05/21/19 12:41
Krystyn 
05/21/19 12:41
Krystyn 
Re: My DC, Topical Verapamil, Genetic Clues and Questions

Yeah, saw that thread. Maybe I should continue this in there.

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Genetic   dupuytren-online   progression   Questions   Channel   progressing   layman’s   disability   Verapamil   signalling   fibroblasts   fibroblast   associated   Bipolar   different   grandmother   Calcium   Caucasians   predispose   interesting