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Role of damaged liver and Dups
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08/12/12 21:48
RedHed 
08/12/12 21:48
RedHed 

Role of damaged liver and Dups

As I`m a newbie and still researching dups, please forgive me if I rehash info that has been discussed before.

I have epilepsy, and take phenobarbital and phenytoin.
I`ve had dups in RH since Oct 11, and in LH since June 12. Just nodules and cords, no contracture.
I`ve also had breast cancer.

When googling "Dupuytrens and lymphedema" I came across an article suggesting that "in a liver that is chronically inflamed, the stellate cells become activated and they multiply and produce excessive collagen". See link below.

http://www.liverdoctor.com/liver-problems/cirrhosis

This interested me greatly because I know that I have a problem with raised alkaline phosphatase (ALP) in my liver, brought to light in a routine blood test last year.

All the risk factors for Dups - alcoholism, smoking, diabetes, anti-convulsants - affect the liver.

http://www.ehow.com/how-does_4565046_smo...fect-liver.html

As far as familial links go, I have no-one in the family with Dups, BUT my mother had cancer of the bile duct.

Perhaps the familial link in general is a weak liver? Most people don`t have liver panel blood tests done because they have no reason to do so, but the results might be interesting.

What does anyone else think?

I am going to concentrate on making my liver as healthy as possible to see if it has any effect on my rapidly advancing nodules and cords

08/12/12 22:02
sorefeet 
08/12/12 22:02
sorefeet 
Re: Role of damaged liver and Dups

I think a lot has to do with the liver but maybe another cause..... Over abundance of yeast /parasites & liver fluke in the digestive track.Brought on by over use of antibiotics & steroids...........http://www.desertallergy.net/newsletters...er-may-2008.asp The part that i found was the most interesting====It can change pathologically from a single cell to a branching fungal form which can multiply rapidly. It uses root-like tentacles to perforate the intestinal wall, damaging cells. Eventually the organism may pass through the intestinal wall and enter the bloodstream and lymphatics and can then travel to other parts of the body. It is surrounded by a connective tissue shell which protects it from the immune system. Researchers have found 17 variations of yeast which allow it to elude the immune system and to resist anti-fungal medications.

Edited 08/13/12 01:13

08/13/12 02:37
Vikingorigins 
08/13/12 02:37
Vikingorigins 

Re: Role of damaged liver and Dups

Redhed, I am really happy that you raise this because it has been on my mind since I found out a few months ago, about the disease that affected my hands. The disease seems to exacerbate in certain periods: when I drink alcohol or eat sugar, I feel itching in my hands almost 2 hours later. quantity does not even seem to matter. The metabolization by the liver should be pursued...
If the disease was mortal, the cause and cure would have been found long time ago. It could be a good idea to have some kind of bursary for research in this disease. I now regret that I chose math and physics, over biology and chemistry when I was a student.

I tried a detoxifying liver diet... I am sure it helped my body... but no effect on nodules or cords....

Edited 08/13/12 03:09

08/13/12 10:15
RedHed 
08/13/12 10:15
RedHed 

Re: Role of damaged liver and Dups

sorefeet:
I think a lot has to do with the liver but maybe another cause..... Over abundance of yeast /parasites & liver fluke in the digestive track.Brought on by over use of antibiotics & steroids...........

So interested that you mentioned this. I have taken far too many anti-biotics over the last 12 months for UTIs (uterine tract infections). Its a catch 22 because I know the ABs are not good for me, but UTIs travel very quickly up to the kidneys if not caught in time. Not to mention their excrutiating discomfort.

Something else to think about / discuss with doc.

Thank you.

08/13/12 10:22
RedHed 
08/13/12 10:22
RedHed 

Re: Role of damaged liver and Dups

Hi Vikingorigins, I totally believe there is a scientific reason for everything.

I`ve a 30 year old son with a very rare chromosome deletion syndrome. We didn`t have a diagnosis for him until he was 7, then.....Voila! and everything slotted into place just like a vast jigsaw.

Its all out there somewhere......

08/13/12 12:23
Larry 
08/13/12 12:23
Larry 
Re: Role of damaged liver and Dups

Both "chronic liver disease" and "anti-epileptic medication" are associated with Dupuytren Disease in the literature;

http://www.ncbi.nlm.nih.gov/pubmed?term=...Liver%20Disease


http://www.ncbi.nlm.nih.gov/pubmed?term=Dupuytren%20Epilepsy

Just explore what has been published ... Larry

08/13/12 14:35
RedHed 
08/13/12 14:35
RedHed 

Re: Role of damaged liver and Dups

Hi Larry, my point was that it seems to be the liver which is the common denominator, not individual illnesses.

I`d no idea that my liver had been damaged until a routine blood test showed it last year. I have no other symptoms. There must be many other people in the same situation.

I did check all the lit before I posted. In my experience with my son, medics are not readily inclined to accept ideas that they haven`t thought of themselves.

However if it was something so simple as a damaged liver, I`m sure that someone would have thought of it before now

08/13/12 16:40
sorefeet 
08/13/12 16:40
sorefeet 
Re: Role of damaged liver and Dups

Your welcome Redhed -------My point was ,i think we all have 1 0f these 17 variations of this yeast / fungus!It is surrounded by a connective tissue shell which protects it from the immune system. Researchers have found 17 variations of yeast which allow it to elude the immune system and to resist anti-fungal medications.

Edited 08/13/12 16:40

09/26/12 15:48
John656

not registered

09/26/12 15:48
John656

not registered

Re: Role of damaged liver and Dups

I tried this link about the fungus and hit a dead end. Can you please provide link again. Thanks.

http://www.desertallergy.net/newsletters...er-may-2008.asp

09/26/12 15:49
John656

not registered

09/26/12 15:49
John656

not registered

Re: Role of damaged liver and Dups

Would a low carb high fat diet starve the fungus even if it is resistant to drugs?

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