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side effects of radiotherapy
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07/08/2012 09:45
Lanod 
07/08/2012 09:45
Lanod 
Re: side effects of radiotherapy

Bethesda - I too have Dupuytrens and I am starting radiotherapy with an RT oncologist who is new to Dupuytrens threatment. I am not at all an MD but I understand you should ask your clinic to follow the so-called 'German protocol' which defines the total 30 Gy dose in two 15 Gy sessions, where there is a 3 month separation between the sessions. The daily dose should be 3 Gy. The hand must be carefully examined (experience needed here) for any palpable nodules, cords - or indeed for any associated diffuse tissue. Then a margin of 2cm should be allowed in the longitutional direction, at both distal and proximal ends, and a margin of 1cm on the sides. I wish you success in your treatment.

Does anybody know where we can find a clear written description of this 'German protocol'? We seem to have radiotherapy clinics starting to support Dupuytrens patients but there seems to a lack of clear protocols or guidelines. For example in the UK the NICE (UK clinical guidelines) are rather vague .. IMO.

Also - on this site people mention cord and nodules - but never a mention of associated diffuse tissue that sometimes can be felt under on skin and is imporant when mapping the hand for RT treatment.

This is great site which is so helpful to us all. Thanks to everyone!

07/08/2012 11:52
alcook101 
07/08/2012 11:52
alcook101 
Re: side effects of radiotherapy

Lanod:
Bethesda - I too have Dupuytrens and I am starting radiotherapy with an RT oncologist who is new to Dupuytrens threatment. I am not at all an MD but I understand you should ask your clinic to follow the so-called 'German protocol' which defines the total 30 Gy dose in two 15 Gy sessions, where there is a 3 month separation between the sessions. The daily dose should be 3 Gy. The hand must be carefully examined (experience needed here) for any palpable nodules, cords - or indeed for any associated diffuse tissue. Then a margin of 2cm should be allowed in the longitutional direction, at both distal and proximal ends, and a margin of 1cm on the sides. I wish you success in your treatment.

Does anybody know where we can find a clear written description of this 'German protocol'? We seem to have radiotherapy clinics starting to support Dupuytrens patients but there seems to a lack of clear protocols or guidelines. For example in the UK the NICE (UK clinical guidelines) are rather vague .. IMO.

Also - on this site people mention cord and nodules - but never a mention of associated diffuse tissue that sometimes can be felt under on skin and is imporant when mapping the hand for RT treatment.

This is great site which is so helpful to us all. Thanks to everyone!

When people refer to the "German" protocol they really mean the protocol used by Prof Seegenschmiedt.

He used two different protocols in his study 1997-2005 using 30Gy as Group A and 21 Gy as Group B.
His conclusions from this study were that the 30Gy approach had better results.
(This information is from YouTube "2010 Miami Dupuytren Symposium Presentation 15")

This information is also in this .pdf file (although there appears to be a problem with the formatting):-
http://degro.wcenter.de/dav/html/kongres...oster/W7-14.pdf

The text of my email from Prof Seegenschmiedt was:
"The usual procedures after the decision for using radiotherapy and
travelling to our clinic in HAMBURG are as follows:

You need a full week with five working days (NB: no holiday in between!).
Within ONE WEEK (usually Monday thru Friday) we complete the FIRST
radiotherapy series using the following fractionation scheme: 5 radiation
treatments of each 3Gy up to a total dose of 15 Gy; a break of 12 weeks
follows; afterwards the SECOND radiotherapy series is applied using the
same fractionation scheme: 5 radiation treatments of each 3Gy up to a
total dose of 30Gy, Thus 10 radiation treatments and 2 separate weeks
are required for the completion of the treatment."

Following the first treatment, I updated this information in Wikipedia "Dupuytren's Contracture", radiation therapy section.

Al

07/08/2012 19:04
Bethesda 
07/08/2012 19:04
Bethesda 
Re: side effects of radiotherapy

Hi, Callie,

I was not quoted a price yet, but I have Aetna health insurance and they will pay for RT for Dupuytren's.

Bethesda

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