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Transdermal Verapamil
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08/16/14 14:16
petricd 
08/16/14 14:16
petricd 
Re: Transdermal Verapamil

Pretty depressing as it had no impact on the size of the tumors and are now after 1 year it is growing again in my feet and hands.

08/16/14 17:14
Lilypad 
08/16/14 17:14
Lilypad 
Re: Transdermal Verapamil

May I ask your age and whether or not you have tried RT?

08/16/14 17:39
petricd 
08/16/14 17:39
petricd 
Re: Transdermal Verapamil

I had RT about a year ago in the US on my palms, knuckles, and both feet. It has had no impact on my condition. I am 49.

11/28/17 05:10
U3962521 
11/28/17 05:10
U3962521 
Re: Transdermal Verapamil

Hi
I am aussie 36 year old now
Started getting dup in LH when 28 just on ring finger
Few years later on right hand affecting ring and index finger
The last year or two am developing garrot pads on every finger except thumbs. Lots of pain particularly first thing in morning can fully close fists both hands
Tried radiation therapy a few years ago didnt seem to do anything
Noticed when i went to a keto diet for 3 weeks my inflammation and pain dropped signficantly but i just couldnt keep diet going as i exercise a lot like running and was feeling like i had no energy. Back to normal diet. Have gone to compoumd chemist im canberra using 15%verapamil eith activemax as the transdermal soln and plan to apply 2-3 times daily.
No peyronies and nothing in my feet yet touch wood as my hands are bad enough.
Will post results as i go
Pharmacy charged $135 for making up 100 grams

I have rubbed it in once now goes on pretty easily a little itch and hands feel a little chalky so i hope the verapamil is going in.

I notice coffee, alcohol, lack of sleep, rock climbing, and weight bearing or hand clenching causes my hands to tingle and my gut feel says a very healthy diet and lifestyle could slow progression.

Miss my climbing

12/05/17 10:33
wach 

Administrator

12/05/17 10:33
wach 

Administrator

Re: Transdermal Verapamil

Did you see the previous comment

"Verapamil is completely ineffective. The only thing it will reduce is your bank balance" ?

The results of Verapamil in our Patient Survey were not very impressive either http://www.dupuytren-online.info/patient_survey.html .

Nevertheless, maybe still worth trying. Every patient is different. Please report your results!

Wolfgang

Edited 12/05/17 10:36

12/30/17 17:38
eddavisdpm 
12/30/17 17:38
eddavisdpm 
Re: Transdermal Verapamil

Transdermal verapamil cream can be effective in the treatment of Ledderhose Disease under the right circumstances.

1) Consider the ability for any topical medication to be able to penetrate the tissue to be treated. The larger the lesion and the “rounder” the lesion, the less the ratio of surface area to interior volume. Under such circumstances the penetration of Verapamil or any topical medication to the target tissue is limited. We see significantly more success in smaller, flatter lesions or lesion that have been reduced in size with fibrinolytic enzymes. The flatter the lesion, the higher the surface area to interior volume thus more of the medication penetrates.

2) Consider prior treatment history. Verapamil, in theory, works by inducement of endogenous fibrinolytic enzymes production. Enzymes act on specific and viable substrates. It has been my experience that prior radiation therapy results in tissue changes leading to significantly reduced activity of fibrinolytic enzymes both exogenous (injected) and endogenous (via stimulation from topical verapamil)

01/04/18 16:32
wach 

Administrator

01/04/18 16:32
wach 

Administrator

Re: Transdermal Verapamil

Interesting comment but looking at our survey results http://www.dupuytren-online.info/patient_survey.html Verapamil doesn't seem to be very effective for treating Dupuytren or Ledderhose disease. Maybe slightly better for LD.

eddavisdpm:
Transdermal verapamil cream can be effective in the treatment of Ledderhose Disease under the right circumstances.

1) Consider the ability for any topical medication to be able to penetrate the tissue to be treated. The larger the lesion and the “rounder” the lesion, the less the ratio of surface area to interior volume. Under such circumstances the penetration of Verapamil or any topical medication to the target tissue is limited. We see significantly more success in smaller, flatter lesions or lesion that have been reduced in size with fibrinolytic enzymes. The flatter the lesion, the higher the surface area to interior volume thus more of the medication penetrates.

2) Consider prior treatment history. Verapamil, in theory, works by inducement of endogenous fibrinolytic enzymes production. Enzymes act on specific and viable substrates. It has been my experience that prior radiation therapy results in tissue changes leading to significantly reduced activity of fibrinolytic enzymes both exogenous (injected) and endogenous (via stimulation from topical verapamil)

01/20/18 16:21
NancyP 
01/20/18 16:21
NancyP 
Re: Transdermal Verapamil

I have heard this treatment was more effective for those who started in early, who had newer, smaller nodules.
I tried Verapamil on several nodules on my foot for more than a year. I did not experience any improvemnt...no softening, no reduction in size or pain. I will say, I started this several years and two surgeries into this disease. I have significant scar tissue and fairly large nodules.

01/20/18 16:25
wach 

Administrator

01/20/18 16:25
wach 

Administrator

Re: Transdermal Verapamil

Hi NancyP, unfortunately your experience seems to be typical for Verapamil . It doesn't seem to be very effective, neither for Ledderhose nor for Dupuytren's https://www.dupuytren-online.info/patient_survey.html . You might also have a look at https://www.dupuytren-online.info/dupuytren_anecdotal.html .

Wolfgang

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