Forum for Dupuytren's and Ledderhose

Re: Theragun percussive therapy device

spanishbuddha — Tue, 26 May 2026 16:43:00 +0000

Hi

People have reported relief, maybe not success, by using various gentle massage techniques, including with some hand massage devices, but afaik not with a percussive device. I would urge caution as the literature reports a DD link between the use of vibration tools, or hand trauma in general. I personally would not risk it based on my own experience of the effects of (mis)using manual tools.

Best wishes SB

Theragun percussive therapy device

hanpat — Tue, 26 May 2026 09:05:54 +0000

Hi,
Has anyone ever used a percussive therapy device, such as a theragun to minimize the effects of the node development that lead to the fingers becoming crooked?
Thanks

Re: Question about pain

StellaS — Sun, 24 May 2026 21:13:32 +0000

Thank you for your response. I have had SFN for 6 years, I am 100% this pain is not due to SFN. Moving my fingers is painful, holding something is painful, the nodules are painful.

I sent a picture of my hand to Dr. Pess in NJ who confirmed the nodule. I am seeing Drs. in person next week.
The acupuncture was 3 weeks ago, I have tried advil, voltaren, nothing works. Verapamil gives me a slight relief.
The fact that I have Ledderhose as well makes it highly likely to develop DD. I know that many people don't have pain early on but I am on the yourger side, which is often linked to pain when the disease is agressive.
What I would like to know if wether the disease will affect all my fingers if I have pain in all my fingers...

Re: Question about pain

spanishbuddha — Sun, 24 May 2026 19:20:43 +0000

Hi Stella

It's not clear from this, and your other posts, if you have been diagnosed by an experienced hand surgeon/specialist as having early stage Dupuytrens, or whether the pain you are experiencing is from DD or some other condition (possibly SFN). Some people do have pain from early stage DD, but it's usually mild, and although you mention nodules, there are other more telling symptoms that would confirm the diagnosis, or provide a differential from other possible causes. May I suggest you could be suffering some after effect of the acupuncture related to SFN or inflammation? I would ask your hand surgeon about (other) possible causes for the non-localised pain, and the options to treat that or the symptom. Examples might be NSAIDS, steroid injection, ice, hand supports (rheumatic compression glove) etc. At this stage I would really not try and second guess the likely rate of DD progression, but as you are doing, try to gather information so that you can use your appointment to ask probing questions.

Best wishes SB

Question about pain

StellaS — Sun, 24 May 2026 17:14:54 +0000

Hi,

I have a hand surgeons and an oncologist appoitment next week.

I am at the beginning of this disease but unfortunatly I feel that I have the agressive version. I was daignosed with Ledderhose in Feb. and a bad session of acupunture with needles in my hand seemed to have triggered DD 3 weeks ago. I have been feeling extremely anxious reading and researching about this disease.

The pain is constant, gets worse when I use my hands and drive.
Nodules are forming in both hands but I also have pain in whole my hands and each fingers. Pain between the thumb and index finger, pain at the base of the thumb, in the palms, under the index and middle finger and nodules below ring and little finger. Sometimes I even get pain in my wrists.

With your experience, having pain in all those areas, do you think it means that I will have all fingers involved with the risk of all of them contracted?

Thank you for your help.

Small fiber neuropathy

StellaS — Fri, 22 May 2026 13:23:59 +0000

Hi everyone,

Does anyone know if having small fiber neuropathy is a contraindication for RT?
I am at the begining of the DD though the extreme pain I have been having in both heands and all my fingers make me feel that it is progressing fast. Do you think that my neuropathy will get worse with RT?

Also, do you know if having so much pain in both hands and all fingers mean that all my fingers are affected by DD?

Colchicine trial

StellaS — Wed, 20 May 2026 23:45:07 +0000

Hi everyone,
I am a new member and I am still trying to get officially diagnosed by a knowleageble doctor (hard to find).
I read a few positive things on the effect of colchicine on DD and I wanted to know if any of you had tried it?

Here are a few links:
https://www.hkcfp.org.hk/Upload/HK_Pract...te_article.html

https://dupuytrens-society.org.uk/treatm...her-treatments/

https://www.linkedin.com/pulse/potential...l-posner-rukuf/

https://pubmed.ncbi.nlm.nih.gov/1568169/

Re: 35y male just diagnosed - reassurance/guidance

Kunal_gaur__ — Thu, 14 May 2026 05:35:49 +0000

I can understand why this feels overwhelming, especially with your family history and having a young child. But the positive thing is you’ve caught it very early, before any real contracture has developed, and treatments/options today are far better than they were decades ago when your grandad dealt with it.

Your plan to monitor it closely, reduce possible triggers, and avoid rushing into radiotherapy without feeling fully comfortable sounds very sensible. Many people with Dupuytren’s progress very slowly, and some never develop severe hand limitation at all. Try not to jump mentally to the worst-case scenario. Staying informed and acting early if things change already puts you in a much stronger position.

Re: 35y male just diagnosed - reassurance/guidance

spanishbuddha — Tue, 12 May 2026 16:38:31 +0000

It's tricky to answer your first question directly as most people seeking help on a forum are having problems associated with ongoing symptoms, progression of contracture or recurrence after treatment. Nonetheless the overall stats remain that the majority of people with nodules, even minor cords, despite having some loss of flexion do not progress to a contracture. In your case it has started at a relatively early age, and so I would be wary and want to keep an eye on it, as indeed you are. But, it happened after an injury, so maybe it will settle now and not flare up again for many years, or just continue to develop slowly. A GP and maybe a surgeon might say wait and see and come back when it's contracted, and most people dislike this response. But the 'wait' part, along with monitoring, is perfectly valid IMHO in most cases because of how slowly it usually progesses (or in cycles).

Catching it early mainly applies to using RT, since the RT treatment hypothesis is based on the disease being in a specific phase of the overall cycle, and this occurs early on, either when it is first noticed, or at the start of a new active cycle. Even then there may be other options such as a steroid shot directly into sore and inflamed nodules, which may calm things down again enough to continue with wait and monitor. RT does not reverse cords so needs be done at the nodule stage with progression, usually accompanied by symptoms or soreness, itching, tingling pins and needles.etc. Early surgical options are not really suitable, unless there is a cord with contracture because the very act of surgery may cause new or further problems (early or immediate recurrence).

I would amend your treatment cascade as follows, but it's only a guide and IANAD:
1 soreness, inflammation, - wait and monitor, and/or steroid shot
2 soreness, nodules, pitting, flexion reduced - wait and monitor, and/or steroid shot, some would suggest radiotherapy
3 further with nodule hardening, early cords, further loss of flexion or signs of contracture - wait and monitor, or radiotherapy
4 moderate progression of contracture - needle aponeurotomy or collagenase (USA)
5 recurrence of moderate contracture - repeat needle aponeurotomy or collagenase (USA)
6 further or advanced progression of contracture - varying options of surgery
but see also this discussion by the pioneer of RT
https://www.dupuytren-online.info/Forum_...1559373063.html
taken from
https://www.dupuytren-online.info/Forum_...1553463816.html

In my own case, I am a 'do something' kind of guy, so at at the 3rd stage in my list I went for radiotherapy.
When it started on the other hand at stages 1 and 2 I again consulted with a view to having radiotherapy (I wanted RT!), but was advised to wait and see, and it was 2 or 3 years later and only with further symptoms that I actually had RT.

Best wishes SB

Edited 05/12/2026 15:41

Re: 35y male just diagnosed - reassurance/guidance

Dunney77 — Tue, 12 May 2026 14:15:08 +0000

spanishbuddha:
Hi again

Alas it's hard to give guidelines on progression as it varies so much from person to person. But for the majority it is a slow developing disease with hardly noticeable changes except over years. Unless there is an injury or surgery and not always on the affected limb. Or you have what is called diathesis which is a case susceptibility to rapid progression.

It's possible your reduced flexion is due to an underlying cord or nodules, maybe you can feel it with the other hand? I have a finger like that and it has remained that way for years, although I have had RT.

Some surgeons are quite against RT, as they are thinking of RT used for in body cancers that leaves damage of fibrous tissue and scarring.

It sounds like you have a plan, monitor progress, get ready for RT if it develops, take care of diet and health, look after the hands and not worry too much. Sounds good to me.

Best SB

Thank you :) I note you post often on the group and provide a lot of support to people, and must also have seen many cases/stories.

Do you often see peoples' cases get worse or is there a chance you may find initial movement on the disease but then it goes silent as such? My mum has had nodules as long as she can remember but never had issues with contractures.

I am also trying to understand why "catching it early" is considered a very good thing for this disease? My GP said it is good but
given the disease often comes back, I am struggling to see why catching it early really does anything? E.g. if you have surgery, which rules you out of future surgery, if it comes back then you have already tried your ace card?

Is there typically a cascading "menu" of treatments as the disease progresses? E.g.
- Nodules / slight loss of hyperextension - do nothing
- Initial commencement of contracture - radiotherapy
- Moderate progression of contracture - needles
- Advanced progression of contracture - surgery?

Re: 35y male just diagnosed - reassurance/guidance

spanishbuddha — Tue, 12 May 2026 12:16:03 +0000

Hi again

Alas it's hard to give guidelines on progression as it varies so much from person to person. But for the majority it is a slow developing disease with hardly noticeable changes except over years. Unless there is an injury or surgery and not always on the affected limb. Or you have what is called diathesis which is a case susceptibility to rapid progression.

It's possible your reduced flexion is due to an underlying cord or nodules, maybe you can feel it with the other hand? I have a finger like that and it has remained that way for years, although I have had RT.

Some surgeons are quite against RT, as they are thinking of RT used for in body cancers that leaves damage of fibrous tissue and scarring.

It sounds like you have a plan, monitor progress, get ready for RT if it develops, take care of diet and health, look after the hands and not worry too much. Sounds good to me.

Best SB

Re: 35y male just diagnosed - reassurance/guidance

Dunney77 — Tue, 12 May 2026 11:58:26 +0000

spanishbuddha:
Hi

Welcome to the forum. There's lots of experience here and on other sites including Facebook that will answer all or most of the questions your early searches have bought up. So, for now I'll just be brief.

It seems that maybe the finger injury preceded the first development of symptoms in your case. This is common, as it often develops after a wrist or hand injury or surgery. However it is usually slow to develop, and in the majority of cases does not lead to a contracture, but 35 is relatively early, but not unknown, to have symptoms. I would start a record,diary,log of symptoms and progression without being overly zealous about it, as it will provide a useful timeline of actual progress, if any, when discussing treatment if that does become necessary.

Down the line there are effective treatments, including as you mention radiotherapy. You may be considered by some to be too young for that, but others younger than you have been treated successfully with radiotherapy. The dilemma is, radiotherapy will 85% or so of the time stop progression, if done when symptoms show active ongoing progression, but often those symptoms and progression stop of their own accord anyway, or occur in cycles. Worries about cancer should be minimal as the dose is low, superficial and applied to an extremity. I have had radiotherapy in both hands 15 years ago or thereabouts, and almost symptom free, but am twice your age. Afaik it remains the case there are no known cases of cancer caused by radiotherapy for DD, and it has been used as a treatment for 30+ years or so, maybe more.

I lift weights, bike, play tennis, garden, modest DIY all with gloves, and baby the hands so exclude plumbing and serious mechanical car repairs.

There's lots more information in the forum and the website, but I am not sure what you mean by Dupuytren's UK, the BDS is your go to if you're in the uk. They have an active FB group.
https://dupuytrens-society.org.uk/

Happy to answer further specific questions here or by PM.

Best wishes SB

Thank you very much!

Yes it is a fine balance on treatment. I have no contracture in the finger (but when lifting finger off table, it raises 2cm lower than the middle finger on my left hand). Would this loss of hyperextension mean I am on my way to contracture, or could it just stop there? Also wondering does contracture always mean that horrible "bending to palm" fixing or could it stop say 30 degrees?

Given no contacture, I am minded to record monthly measurements and get on with my life and see how it progresses (my mum has had nodules all her life but no contraction issues). If any change, minded to then proceed to radiotherapy - however, can the disease move so quickly I "miss the boat"? Would be paying private so treatment could be administered very quickly.

I am seeing two surgeons in next two weeks though for their advice / how they view radiation on future surgeries.

Re: 35y male just diagnosed - reassurance/guidance

spanishbuddha — Tue, 12 May 2026 11:25:18 +0000

Hi

Welcome to the forum. There's lots of experience here and on other sites including Facebook that will answer all or most of the questions your early searches have bought up. So, for now I'll just be brief.

It seems that maybe the finger injury preceded the first development of symptoms in your case. This is common, as it often develops after a wrist or hand injury or surgery. However it is usually slow to develop, and in the majority of cases does not lead to a contracture, but 35 is relatively early, but not unknown, to have symptoms. I would start a record,diary,log of symptoms and progression without being overly zealous about it, as it will provide a useful timeline of actual progress, if any, when discussing treatment if that does become necessary.

Down the line there are effective treatments, including as you mention radiotherapy. You may be considered by some to be too young for that, but others younger than you have been treated successfully with radiotherapy. The dilemma is, radiotherapy will 85% or so of the time stop progression, if done when symptoms show active ongoing progression, but often those symptoms and progression stop of their own accord anyway, or occur in cycles. Worries about cancer should be minimal as the dose is low, superficial and applied to an extremity. I have had radiotherapy in both hands 15 years ago or thereabouts, and almost symptom free, but am twice your age. Afaik it remains the case there are no known cases of cancer caused by radiotherapy for DD, and it has been used as a treatment for 30+ years or so, maybe more.

I lift weights, bike, play tennis, garden, modest DIY all with gloves, and baby the hands so exclude plumbing and serious mechanical car repairs.

There's lots more information in the forum and the website, but I am not sure what you mean by Dupuytren's UK, the BDS is your go to if you're in the uk. They have an active FB group.
https://dupuytrens-society.org.uk/

Happy to answer further specific questions here or by PM.

Best wishes SB

Edited 05/12/2026 10:43

Re: CoQ10 and Dupuytrens

Tobi89 — Tue, 12 May 2026 09:07:20 +0000

I have started Q10 after I got Peyronie's at 31yo. I use 100mg Ubiquinol for 3 years now. In the meantime I have developed Morbus Ledderhose and a 2nd Peyronie's nodule. I think they are unrelated.

My guess is:
Q10 helps patients on statins as statins deplete Q10. This can lead to issues in the wound healing process. So for patients with a deficiency it might make a difference, for other maybe not. But no one will know for sure as there are no clear studies on it.

In the Peyronie's community it is taken regularly, but far from a miracle drug. I use it during active phases of Peyronie's to have a tiny bit feeling of control and that I did something.

35y male just diagnosed - reassurance/guidance

Dunney77 — Tue, 12 May 2026 08:46:23 +0000

Hi all,

I am a 35 year old male who went to visit Dupuytren UK this afternoon.

A background, I lost the tip of my middle finger (right hand) 4 years ago. Around 3 years ago I developed a lump in the palm of my right hand under that middle finger. A smaller, second module has since developed. I also have a knuckle pad middle knuckle of that finger.

I was told I have Dupuytren’s Disease. No contracture yet and all my flexibility measurements were okay other than I have lost 2cm extension in that middle finger (so can still raise it on table test but not as far back as by left middle finger ).

Doctor said there is a chance it may progress, chance it may not, although my risk factors suggest it might - my grandad had the disease quite bad and my mum has it (although no contracture at all).

Doctor - Dupuytren’s UK - suggested radiotherapy to see if we can’t halt progress. Being 35 and having a maternal side history of skin cancers (including pre-malignant moles removed on my own body), I am hesitant to do it.

Just wondering if anyone else has had radiotherapy here and if it worked for them (appreciate it may be it just doesn’t develop naturally). My queries:

- were there bad side effects
- did it help at all
- Is there a risk that doing it might impact the ability to have surgery in the future (e.g. due to thinner skin)
- Is it true that the forms of cancer it may cause later down the line aren’t typically serious skin cancers (e.g. not melanoma)
- Did anyone find it actually hindered their disease and supercharged it? I query the damage being done to the cells in the area.

Studies seem limited and I note radiotherapy isn’t offered in many countries. So want to do my research.

I’ve spiralled a bit mentally as I really fear I will end up like my grandad and lost the use of my hands (although he had it 50-60 years ago and never had any treatment).

Given I have no contracture (in fact, 2.5cm extension), I’m minded to wait and see how this develops as I understand you can have the treatment up until c.10 degree contracture. Also:

- lessen alcohol intake
- Avoid heavy lifting weights (+ wear gloves for light weights). Only found this out today as a risk factor
- Keep monitoring monthly so I can move early and quickly should anything change
- Keep an eye on the other fingers

Any positive words would really help :) I’m hoping it’s just wait and see, but if we need to act there are surgical options. I’m only 35 and just had a little baby, so just a bit gutted i might have a future where I can’t be the dad I want to be with her.

Thanks for reading - any advice / experience would be appreciated.

Re: CoQ10 and Dupuytrens

spanishbuddha — Mon, 11 May 2026 21:38:59 +0000

Greenytx:
spanishbuddha:
Hi Poppy
On the BDS Facebook group for DD and LD there are few, mostly positive, experiences from people who have explored the benefits of taking COQ10. As you say these are mostly anecdotal, self selecting to give positive feedback, and usually without longer term follow up. But anyway it will be interesting to hear about your outcome or views after a few months.
Best wishes SB

@spanishbuddha
What is the BDS Facebook group??

The Facebook group run by the British Dupuytrens Society. It is open to all and has lots of patient interaction and experiences.
https://www.facebook.com/britdupsoc/

Re: CoQ10 and Dupuytrens

Greenytx — Mon, 11 May 2026 17:56:26 +0000

spanishbuddha:
Hi Poppy
On the BDS Facebook group for DD and LD there are few, mostly positive, experiences from people who have explored the benefits of taking COQ10. As you say these are mostly anecdotal, self selecting to give positive feedback, and usually without longer term follow up. But anyway it will be interesting to hear about your outcome or views after a few months.
Best wishes SB

@spanishbuddha
What is the BDS Facebook group??

Re: Anti-Inflammatory Diet and/or No Gluten & Dairy

stinger88 — Mon, 11 May 2026 14:51:35 +0000

Kunal_gaur__:
My uncle has Dupuytren’s too, and while diet didn’t stop progression, he did notice less stiffness after reducing sugar, processed foods, and dairy. No proven cure from diet, but an anti-inflammatory approach seemed to help overall hand comfort.

Thank you!

Re: Anti-Inflammatory Diet and/or No Gluten & Dairy

Kunal_gaur__ — Mon, 11 May 2026 06:38:10 +0000

My uncle has Dupuytren’s too, and while diet didn’t stop progression, he did notice less stiffness after reducing sugar, processed foods, and dairy. No proven cure from diet, but an anti-inflammatory approach seemed to help overall hand comfort.

Re: Dupuytren's Diathesis Patients with Progressive Peyronie's Life Experience

spanishbuddha — Sat, 09 May 2026 16:49:31 +0000

Hi

I can't help directly but want to make sure you know the BDS has quite a bit of info on PD:
https://dupuytrens-society.org.uk/inform...ronies-disease/
https://dupuytrens-society.org.uk/treatment-2/peyronies/
https://dupuytrens-society.org.uk/inform...seful-websites/
https://www.inspire.com/resources/mens-h...ocate-gislason/

Best wishes SB

Dupuytren's Diathesis Patients with Progressive Peyronie's Life Experience

Tobi89 — Sat, 09 May 2026 09:13:26 +0000

Hi Everyone,

I have Morbus Ledderhose (started 36yo) and Peyronie's Disease (started 31yo), Knuckle Pads (started at 17yo). My hands are itchy a bit, but not yet clear sign of nodules or contraction. My father had DD, ML and PD.

Now especially my Peyronie's Disease reactivated with a 2nd nodule after being stable for 5 years. I did not have a clear trauma so I suspect I need to be prepared for lifelong progression.

Therefore, I wanted to ask if there are patients in a similar category that have the disease for multiple years or decades and can give me some life advice especially in regards to Peyronie's Disease.

On Peyronie's Disease patient groups there are strangely not many patients with DD or ML and typically consists of patients with a clear trauma or penile fracture.

As this is a quite personal topic I would be super happy to exchange via direct messages or a video call, etc.

Thank you and kind regards
Tobi

Re: Anti-Inflammatory Diet and/or No Gluten & Dairy

stinger88 — Tue, 28 Apr 2026 18:45:43 +0000

wach:
On this website you can find comments on diets at the end of https://www.dupuytren-online.info/dupuyt...apies-research/ . They agree with your findings that there is no medical evidence for effective diets against Dupuytrens, just anecdotes about this or that diet.

Wolfgang

Thank you. I may just try a low alcohol, high protein, high fiber, low-sugar diet and see if that helps.

Re: Anti-Inflammatory Diet and/or No Gluten & Dairy

wach — Tue, 28 Apr 2026 06:51:32 +0000

On this website you can find comments on diets at the end of https://www.dupuytren-online.info/dupuyt...apies-research/ . They agree with your findings that there is no medical evidence for effective diets against Dupuytrens, just anecdotes about this or that diet.

Wolfgang

Anti-Inflammatory Diet and/or No Gluten & Dairy

stinger88 — Mon, 27 Apr 2026 20:51:43 +0000

Has anyone found success from dietary changes? I've had people tell me that anti-inflammatory diets or removing gluten & dairy will stop Dupuytrens from advancing, but I can't seem to find any real data on it. My doctors have told me there is no correlation, but to be honest, I don't trust that they really know anything. Curious if anyone has found success.

I've had Xioflex injections and surgery. My surgery finger has come all the way back and needs surgery again. If there was a way to stop this with diet, I'd be dumb not to try it.

Thank you.

Re: Just Finished First Course of Radiation at Duke Cancer Center with Dr. Larrier in Durham NC, USA

spanishbuddha — Sat, 18 Apr 2026 20:48:00 +0000

jonthepain:
btw for those who read my RT story from 2018, Mom passed away shortly after those treatments, on Christmas Eve 2018.

Hi again
Thanks again for sharing your Dups RT story. Sorry to hear about your Mom. Also best wishes for the PC recovery (another example that there can be worse things than Dups to worry about) do the physio, be patient, and hopefully at your age you'll overcome the surgery side effects too.
Best wishes SB

Re: Just Finished First Course of Radiation at Duke Cancer Center with Dr. Larrier in Durham NC, USA

jonthepain — Sat, 18 Apr 2026 18:45:34 +0000

btw for those who read my RT story from 2018, Mom passed away shortly after those treatments, on Christmas Eve 2018.

Just Finished First Course of Radiation at Duke Cancer Center with Dr. Larrier in Durham NC, USA

jonthepain — Sat, 18 Apr 2026 18:25:26 +0000

Hey All,

I'm back!

In 2018 I had two courses of one treatment a day for five days, spaced 5 weeks apart, with Dr. Larrier at Duke Cancer Center in Durham NC. This stopped the progression of contracture in my left hand. That journey was documented at https://www.dupuytren-online.info/Forum_...1533846222.html

Now my right hand has developed nodes, cords, and contracture, not just in my ring and middle finger as in my left hand, but in all fingers. It seems to be a particularly fast paced progression of contracture, as in two months time my fingers have contracted to about where my other hand was stopped with radiation therapy back in 2018.

The big difference this time is that I am not concerned. The 2018 treatments worked perfectly, so I contacted Duke and Dr. Larrier as soon as I was diagnosed by my primary doctor. It was great to see Dr. Larrier and her team again.

I just finished my first course of five treatments over five days. My next course starts on June 1.

I would like to say that being in the Radiation Oncology department really puts things in perspective. While obviously I would like to keep the use of my right hand, I am in nowhere near the situation that the vast majority of the patients I see back in the treatment areas are in. Particularly heartbreaking is seeing small children back there. I am truly blessed to have this condition and not what most other patients around me have.

The week before last I had prostate surgery, and am recovering nicely. The treatments at Duke are a breeze in comparison, especially knowing that they were completely effective in stopping the progression of the contracture in my other hand.

As always, Dr. Larrier and the team at Duke are outstanding. They are extremely caring and upbeat. I couldn't ask for a better crew.

DMSO & fenbendazole not Nicotine Oil

rttech — Wed, 08 Apr 2026 00:13:12 +0000

Ok new video from Dr Lee Merritt,
She has incorporated the DMSO with fenbendazole which is meant to remove the contracture and easier to use than nicotine as no overdose risk, I'm also starting with the same.

PRP + ASC

Tobi89 — Fri, 03 Apr 2026 06:22:12 +0000

Being new to Ledderhose Disease and an AI engineer I created a system to check for the most promising therapies that might come.

The most interesting is a study (in nude rats, so no active immune system, which could be achieved by combination with steroids) that showed that specifics stem cells with PRP can be used to turn overactive myofibroblasts into passive fat cells. Much nicer to step on squishy fat than thick collagen scars...:
https://pubmed.ncbi.nlm.nih.gov/37480917/

This is all science, but a case report just showed the positive effect of PRP alone on a patient in Dupuytren's:
https://athenaeumpub.com/wp-content/uplo...a-Injection.pdf

This makes me wonder if it would be sane for me to to try to find a PRP specialist as I am in early phase Ledderhose before doing Radiotherapy, knowing that it is extremely experimental.

As I also have Peyronie's disease I know that PRP was tested in Peyronie's patients with mixed results as a monotherapy. But one thing that appears to be crucial is timing it in early disease states which is something not really accounted for in most studies as Peyronie's is often treated with "wait and see 1-2 years, then treat with surgery or collagenase".

I think it is time to be hopeful that in 10 years some of these regenerative procedures are more widely tested and hopefully available.

Anyone on the forum who tested PRP?

Re: Hyaluronidase Injections - Long Term Recurrence Experience

Tobi89 — Wed, 01 Apr 2026 17:44:31 +0000

Yes, but I hoped to get long term Recurrence experience on this separate forum to get more neutral? responses :). But I will check out the FB Group.

Re: Hyaluronidase Injections - Long Term Recurrence Experience

spanishbuddha — Wed, 01 Apr 2026 16:25:48 +0000

Hi

We have a few threads or posts about the experiences of using Dr Davis' protocol, and in case you have not checked it out one of the more positive ones is here, although it may not answer your specific questions.
https://www.dupuytren-online.info/Forum_...roma-1_335.html

I assume you are also aware that Dr Davis hosts (moderates) a FB group on this?

Best..SB

Hyaluronidase Injections - Long Term Recurrence Experience

Tobi89 — Wed, 01 Apr 2026 10:44:04 +0000

Hi All,

I have seen a couple of posts on positive experience with Hyaluronidase Injections following the protocol of Dr. Davis.

I am currently deciding between watchful waiting, then Hyaluronidase, then RT in case of aggressive Recurrence VS early radiotherapie.

My age is 36 so kind of young for RT. I would like to push the timing for RT as much as possible.

---

For those that had success with hyaluronidase injections: How did it develop over the course of many years? I am mostly interested if the original nodules grew back or if the injection stitch caused scarring on its own. Was it then possible to repeat the treatment?

Thank you for your experiences.

Re: DMSO & Nicotine Oil

spanishbuddha — Tue, 31 Mar 2026 07:24:35 +0000

If you search the forum you can find a few questions and experiences of using DMSO usually with potassium iodide. Care needs to be taken as DMSO transfers whatever's on the skin through to the blood stream. In some cases of using it with SSKI there have been (anecdotal) reports of interference with thyroid function as a result. It most often comes up as a treatment for nail fungus when mixed with various agents, but with dubious results. I have not heard of using it with nicotine before or for DD, but presume there will be a risk of nicotine addiction or intolerance, and related side effects, just like with smoking or vaping nicotine. In any case there are almost no anecdotal reports of success using DMSO/SSKI with Dupuytrens. I personally would not try this but thanks for reporting it anyway.

Re: DMSO & Nicotine Oil

Greenytx — Mon, 30 Mar 2026 21:38:04 +0000

Interesting... I had never heard of DMSO before. Just did quick research and while it seems like it would be good, I read it's not for long term use and my hand is in pain pretty much everyday and some side effects are garlicy breath! Yuck - did you experience that? Secondly, as a former smoker (been over 10 years now) I am thinking doing the nicotine oil would not be good for me. But I am going to ask my doctor about the DMSO.

DMSO & Nicotine Oil

rttech — Mon, 30 Mar 2026 21:20:01 +0000

I'm 76 year old man living in Sydney Australia. I had surgery on my left hand 10 years back and removed the contraction which had the ring finger at 90° to my hand, surgery was successful and hand has returned to normal.
3 Years back I noted growths were commencing on my RH, I work full time and use keyboards for typing and that new growth was going to stop me working. So I commenced to rub DMSO into the area as I already very good results from using DMSO to free up my body from age related changes.
The DMSO on its own appeared to halt the growth from expanding but did not reduce the growth.
Dr Brian Ardis posted work using nicotine patches and I was using them and found it hard to keep the patch on and decided to purchase some nicotine oil from an essential oil vendor and commenced to use DMSO and nicotine oil on another areas not related to Dupuytren's Growth.
I replaced the DMSO only to a mixture of 3 DMSO : 1 Nicotine oil and commenced to rub it in the Dupuytren's Contracture occurring on the right hand.
I applied every 3-4 hrs, Nicotine has a 4 hr life in our body.
2 months later, now, the Dupuytren's Contracture occurring on the right hand is in full remission, my body is removing the growth, (can't feel it) and I can get my hand flat onto the surface when doing push ups, that feeling of the hand flat without the burning as the growth is stretched can only be appreciated by a Dupuytren's Contracture sufferer.
Warnings, very easy to overdose with nicotine, when you over dose you realise nicotine is not a party drug, not fun, not super dangerous, goes in 3-4 hours.
The mixture of 3:1 of DMSO:Nicotine, 4 drops will give an overdose though this disappears a lot as your tolerance builds up and on the hand harder to overdose. When I did it, it was on the back of my head.
Easy to fix, increase the amount of DMSO to 6:1 or 8:1 but I have not tried those ratios,
I'm using 3:1 and that appears to be able to reduce the Dupuytren's Contracture damage back to a non annoying stage in 3-4 months topically applying, I'm not sure what occurs at the end and I'll repost when that occurs, and please remember, this is not medical advice, just what I tried and what occurred

Re: Duputyren NA Experience

Handyman — Tue, 24 Mar 2026 14:55:49 +0000

Practitioner used local anaesthesia injections.

Re: CoQ10 and Dupuytrens

spanishbuddha — Mon, 23 Mar 2026 21:03:16 +0000

Hi Poppy
On the BDS Facebook group for DD and LD there are few, mostly positive, experiences from people who have explored the benefits of taking COQ10. As you say these are mostly anecdotal, self selecting to give positive feedback, and usually without longer term follow up. But anyway it will be interesting to hear about your outcome or views after a few months.
Best wishes SB

Re: Duputyren NA Experience

spanishbuddha — Mon, 23 Mar 2026 20:51:58 +0000

Hi
Thanks for sharing your situation and NA experience. Given questions on other recent and related threads on using local anaesthesia for NA, to be aware of nerve proximity during the procedure, or a more general anaesthetic, can you also say what anaesthetic you had since you have ongoing nerve related symptoms.
Thanks

Duputyren NA Experience

Handyman — Mon, 23 Mar 2026 19:38:40 +0000

FWIW: My NA experience (Dupuytren’s) - left small finger PIP ~35°

Clinical brief (pre-procedure)

Primary issue: Left small finger PIP flexion contracture ~35°, partially correctable; positive tabletop test
Other findings: Palmar cords; left thumb oblique cord
Prior treatment: None (no surgery, no collagenase/Xiaflex)
Goal: Regain extension with a minimally invasive option (NA)
Age: 55

History: My small-finger contracture progressed aggressively over ~18 months prior to treatment.

Why I chose NA vs. Xiaflex vs. surgery
I chose NA based on my read of the tradeoffs: effectiveness (especially for my stage), risk profile, downtime, and cost.

Major-institution hand surgeon consult (U.S.)
Options offered: Xiaflex, open surgery, and (surprisingly) amputation.
NA was not offered in that office.

Xiaflex (collagenase) – what I was told

Risks discussed: including rare but serious issues like tendon injury/rupture (the way it was explained to me was “the tendon could be affected”).
Recovery: days (with bruising/swelling expected).
Estimated cost quoted to me: $14,000–$21,000 (breakdown given: ~$13,400 for Xiaflex + ~$600 for injection procedure; total dependent on billing/coverage).

Open surgery – what I was told

Risks discussed: infection and neurovascular/tendon injury (general surgical risks).
Recovery: weeks with therapy/splinting.
Estimated cost quoted to me: $5,000–$15,000 (again dependent on billing/coverage).
NA practitioners (U.S. and Europe) – what I found

NA (U.S. practitioner)

Risk discussed: low overall; nerve irritation/injury was specifically mentioned (I was told roughly “~0.5% chance,” though exact rates vary by series and definition).
Recovery: 2–3 weeks to settle down, then ongoing remodeling.
Cost: ~$1,500.

NA (Europe practitioner)

Similar risk/benefit framing.
Cost quoted to me: ~€400.

Outcome (my experience)

I chose NA with a U.S. practitioner.
Practitioner used local anaesthesia injections.
Range of motion improved a lot in my little finger and thumb.
I experienced sensory symptoms consistent with nerve irritation/injury in the little finger (numbness/tingling/sharp pain on impact).
At 6 weeks, sensation has improved somewhat, but I still have residual symptoms and expect it may take several additional months to see more significant recovery.

Notes

This is just my experience and the quotes/costs I personally received - pricing and options vary a lot by provider, region, and insurance.

Edited 03/23/2026 19:55

Re: CoQ10 and Dupuytrens

Poppy — Mon, 23 Mar 2026 17:15:53 +0000

Greetings
this is my first post, I had searched on coq10 and Dupuytren’s and was surprised to find this thread. I was searching on Coq10 because of two articles.
The first is from a physician whose patient reports that his DD improved with use of COQ10. Here’s the article
Could coenzyme Q10 be the treatment for Dupuytren's disease?
https://pmc.ncbi.nlm.nih.gov/articles/PMC6398680/

The problem with this article is the same problem with the above post theorizing that COQ10 causes or triggers DD- it’s anecdotal, it’s one patient’s experience. It’s a case report. It has value, but limited. And we don’t have good bio markers to run a blood test and say this is effective.

However, the research into Peyronie’s and COQ10 is more substantive. For example
Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study
https://pubmed.ncbi.nlm.nih.gov/20720560/
Note that this article was covered in the journal Nature, and cited.
https://www.nature.com/articles/ijir201020

So solid enough for me to pursue as a remedy not a cause. Not that I have Peyronie’s— but I have Dupuytren’s in both hands, Ledderhose in both feet, and I have had frozen shoulder twice. I’m sure if I had the organ, I’d have Peyronie’s. I assume I have Dupuytren’s Diathesis. I have just started taking COQ10.
I think that we all need to be cautious. It’s a chronic disease that is not well understood.
I’ll let you know how my COQ10 regimen goes.

Edited 03/23/2026 21:07

Re: 20-year update: Needle release vs surgery

pixi — Mon, 02 Mar 2026 14:58:36 +0000

Good to still see you guys here!

SB, in that second example it sounds like the patient was out for the entire procedure, which is what I was hoping for. Maybe things have changed in the past 10 years and surgeons want the patient more awake?

Wolfgang, it was crazy painful for everything—both the local anesthesia injections (of which I had over a dozen), and the needling. Never screamed so much in my life, not even in childbirth.

Re: 20-year update: Needle release vs surgery

mikes — Sat, 28 Feb 2026 17:58:51 +0000

I had needle release (NA) way back in 2006 with Dr. Keith Denkler in Larkspur, CA. Overall, a massive success. He used a local anesthetic with about 8-10 injections. As the # of injections increased so did the pain associated with each one. It was indeed excruciating. The breaking of the chords was 100% pain free. I felt nothing at all. After the procedure I also felt no pain associated with the procedure.

Re: 20-year update: Needle release vs surgery

wach — Sat, 28 Feb 2026 09:06:03 +0000

Hi pixi,
I had needle release about 10 years ago. I was fully awake and had a little local anaestesia - and no pain at all. When did it hurt for you? When you got the injection or when the doctor poked the cord or when he tried to break it? As Henry wrote, the patient must be awake to report tingling when the needle approached a nerve.

Wolfgang

Re: 20-year update: Needle release vs surgery

spanishbuddha — Fri, 27 Feb 2026 21:17:50 +0000

Hi pixi

I've not had NA so can't comment from experience. I think many surgeons doing NA prefer the patient awake so that they can say if they experience 'electric shocks' if the needling gets too close to a nerve. This does not prevent the use of some partial local anaesthetic to help with pain though. I think an example is in a thread here, and maybe you can discuss this with your surgeon?
https://www.dupuytren-online.info/Forum_...57022254.html#4

There is another example thread of someone having NA under a more full anaesthetic, it doesn't sound like a general but enough so they dont remember the experience, see this thread. It may depend on how close the cords and proposed needling is to the nerves in the palm or fingers as to what the surgeon wants to do. You could ask about this too?
https://www.dupuytren-online.info/Forum_...nce-0_2042.html

Best wishes SB

20-year update: Needle release vs surgery

pixi — Fri, 27 Feb 2026 20:23:35 +0000

Hi, all. Long story short:

2012: Surgery for right thumb contracture. That surgeon said he had removed the "pulley" so the thumb would never contract. And indeed, it hasn't. Total success.

2022: Surgery for left thumb contracture. I had asked surgeon to also operate on the left index finger which had started to contract. He said to leave it alone. He also did not remove the pulley.

2024: Left index finger further contracted; left thumb contracting again. Did needle release with only local anesthesia, which was terribly painful.

1.5 years later here I am with further contraction in left index finger and thumb. So now I am torn between needle release and surgery.

Surgeon says he could give me sedation for the needle release, but it would not be pain free as I need to be awake enough to tell him if he's getting too close to a nerve. That scares me, as the pain was so intense during the needle release.

Has anybody had needle release under sedation? How bad was it compared to local anesthesia?

Or should I just do surgery again? I'm 51 years old. No palmar chords. Knuckle pads on most fingers.

Edited 02/27/2026 19:24

Re: Summary of NA procedure done by Dr Manet (Paris) in November 2021

Guitareth — Mon, 16 Feb 2026 09:13:21 +0000

Just thought I'd give an update to my past above. I still swear by the Needle Aponeurotomy (NA) treatment method myself. Yes the problem typically returns after between 2 and 5 years (typically 3 for me) but I found it much better than the full hand surgery which I originally got done in 2015. I've now been to Dr Manet in Paris for for the NA treatment 3 times (Nov 18, Nov 21, and Dec 23) and am still happy to recommend that option.

Since my last treatment in December 2023 I bought and have been wearing a special splint glove in bed EVERY night. It's called the FixxGlove (see http://www.fixxglove.com/), and that seems to have helped considerably as my right hand has hardly changed at all since my Dec 23 operation, so I shouldn't need to return so soon for NA. Note the "FixxGlove" is no use for treating the problem - it's only good for maintaining your fingers as straight as possible AFTER you've had the needle surgery.

By the way, I have also attached the document I wrote in 2019 about the NA procedure and my own experiences of it with Dr Manet in Paris. Any questions, don't hesitate to ask.

Re: Dermofasciectomy

spanishbuddha — Wed, 04 Feb 2026 21:08:33 +0000

Greenytx:
@spanishbuddha

Is there a difference in Dermofasciectomy and just Faciectomy?

Thanks
KG

Dermofasciectomy usually refers to those cases where the (some) overlying skin is removed and replaced by a skin graft. A surgeon would advise the necessity for a particular case, but it is likely used for more severe cases where more tissue is removed to prevent recurrence.

Re: Dermofasciectomy

Greenytx — Wed, 04 Feb 2026 19:48:46 +0000

@spanishbuddha

Is there a difference in Dermofasciectomy and just Faciectomy?

Thanks
KG

Re: Dermofasciectomy

spanishbuddha — Sun, 25 Jan 2026 20:57:11 +0000

Hi

We have a list of recommended NA surgeons on the website, some also do open hand surgery.
I would start by calling Dr Gary Pess to see who he would recommend if not himself, or one of the Drs listed for Florida.
https://www.dupuytren-online.info/na-list-north-america/

Best wishes SB

Dermofasciectomy

SLG11 — Sun, 25 Jan 2026 19:32:28 +0000

Hi all,
I am a 68 year old female with DD for 30 years. Have had radiation, na, xiaflex, 3 fasciotomies. Also have LD disease which responded nicely to radiation. I think it’s time for a Dermofasciectomy. I live in NY and Fl but am willing to travel for treatment. My current surgeon does not perform this procedure. Would appreciate any info.
Thanks,
Susan