thank you Keith for your interest and helpful background information. I've had many operations on my left foot then no more growths after a fascia excision. My surgeon explained to me the skin/fascia connection with fibromatoses.
Dr Lermusiaux has replied and has expressing his interest and is investigating Imiquimod.

The more I read about this drug, the more I believe it has potential in treatment of Dupuytren's. The mode of action of the drug should counteract the production of the fibroblasts, and may even reduce the size of the cords and the nodules. I hope a drug company will pick up on this and do some controlled studies....we have suffered enough.
The collagenase has less potential, in my opinion, because it will still have to be injected and whenever you have to inject a drug....there is a much greater risk of potential serious side effects. I am so happy that many of you out there are helping us get the word out about this potential treatment!!

Dupuytren's, Peyronie's and Lederhose are virtually the same condition in different parts of the body. Collectively they're someties referred to as 'superficial fibromatoses'. What works for one should work for all.

Larry,

While a controlled study of the off label use of Imiquimod would be nice, it certainly is not required if a high percentage of patients report significantly positive results. There are a lot of drugs that are prescribed "off label" for conditions unrelated to the treatment it was approved for. Some uses are backed by published clinical studies of effectiveness, other are not. All that's needed is a doctor that believes a medication could be of value to a particular patient. Some MD's are more conservative, needing to see published studies, others will go with what they hear from colleagues.

Right now there aren't any studies on Imiquimod for Dups. And unless we have people willing to step up and try it, there *never* will be. I say bully for those who can get their hands on this (or should I say "get it on their hands") and give it a go. I would like to be among them.

3M happens to own this medication under the name Aldara. (see Aldara.com). The safety profile looks good. All the FDA found was skin irritation.

Larry,

How are you covering the cream so you don't rub it off at night while sleeping?