I am interested in any information on Xiaflex as a enzyme injection for the treatment of Ledderhose It was recently approved by the FDA for the treatment of dupuytren contracture and it is my understanding that dupuytren and Ledderhose are very similar. The reports I have been reading indicate favorable results for dupuyren when treated with Xiaflex.

Is there reason to believe that Xiaflex will become a successful 'off lable' treatment for Ledderhose? It will definitely be "off label" because the expense of getting FDA approval will not justify the maker of Xiaflex getting it approved.

Thanks

David26:

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someone with more expertise can answer better but my understanding of what I've read is that Ledderhose disease is more about nodules and less about contracture, that is a little different than DD. Xiaflex is a treatment for cords and the related contractures, so I'm thinking it would not be considered for nodular treatment. If you had contractures of the toes, it might be an option.