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12/21/2015 17:57
Aber01 
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12/21/2015 17:57
Aber01
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Anti-TNF treatment of DD study - University of Oxford
Hi there
Just came across the following clinical trial in the UK:
http://www.controlled-trials.com/ISRCTN2...pe=basic-search
It seems that Prof. Nanchahal runs a serious trial using anti-TNFs to treat early stage DD. I am just wondering if any of you is participating and if so what your experience is. Do you know of any other study / trial run elsewhere using anti-TNFs? Anti-TNFs seem to be more promising than the usage of Imiquimod, etc.
Thanks,
Axel
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12/22/2015 08:00
wach  Administrator
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12/22/2015 08:00
wach Administrator
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Re: Anti-TNF treatment of DD study - University of Oxford
Not an answer to your question but maybe interesting: Prof. Nanchahal reported on his idea of using TNF as a target at the Groningen conference in May 2015. A video of his presentation is available on https://dupuytrensymposium.org/scientific-program-groningen/ (session 2) .
Wolfgang
Edited 12/30/20 17:30
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03/28/2017 18:45
Luciferette 
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03/28/2017 18:45
Luciferette
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Re: Anti-TNF treatment of DD study - University of Oxford
Aber01:
Hi there
Just came across the following clinical trial in the UK:
http://www.controlled-trials.com/ISRCTN2...pe=basic-search
It seems that Prof. Nanchahal runs a serious trial using anti-TNFs to treat early stage DD. I am just wondering if any of you is participating and if so what your experience is. Do you know of any other study / trial run elsewhere using anti-TNFs? Anti-TNFs seem to be more promising than the usage of Imiquimod, etc.
Thanks,
Axel
Hi Axel,
I've had an invite to chat to the team running it as a possible participant. I've not decided yet whether to join the trial - it's a long way from where I live and would be pretty difficult for me to fit round my job. Also, they inject directly into the growing nodules...mine are in my PIP joints and are sore enough as it is! They said they give a local anaesthetic which "can help" with the pain of the needle but I have to say I'm a bit of a wimp.
I will talk to them, though, and get the full details of what is involved. I suppose I'm young enough for them to follow afterwards (they said 5 years, tracking how long until my next surgery etc), although the effect on the immune system does concern me a little. Also, half the participants get a placebo (run as a totally blind trial) - there are currently only two patients signed up, so there's a good chance I wouldn't get the drug anyway :)
Will post on here how it goes (I've mentioned the trial in a separate, previous post on the Dupuytren's forum).
Ps. My dad and partner want me to do it, my mum and best friend don't...is this a men vs women divide I wonder?!
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