My hand is still doing great since I stopped the CoQ10. I can still feel the one cord when I press down on that area of my palm. The one nodule is still there. It may have decreased a little more in the last three months, but not significantly and more importantly, it has not progressed. Personally, I will never go near C0Q10 again. That is how much I feel it impacted my Dupuytrens.

Greetings
this is my first post, I had searched on coq10 and Dupuytren’s and was surprised to find this thread. I was searching on Coq10 because of two articles.
The first is from a physician whose patient reports that his DD improved with use of COQ10. Here’s the article
Could coenzyme Q10 be the treatment for Dupuytren's disease?
https://pmc.ncbi.nlm.nih.gov/articles/PMC6398680/

The problem with this article is the same problem with the above post theorizing that COQ10 causes or triggers DD- it’s anecdotal, it’s one patient’s experience. It’s a case report. It has value, but limited. And we don’t have good bio markers to run a blood test and say this is effective.

However, the research into Peyronie’s and COQ10 is more substantive. For example
Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study
https://pubmed.ncbi.nlm.nih.gov/20720560/
Note that this article was covered in the journal Nature, and cited.
https://www.nature.com/articles/ijir201020

So solid enough for me to pursue as a remedy not a cause. Not that I have Peyronie’s— but I have Dupuytren’s in both hands, Ledderhose in both feet, and I have had frozen shoulder twice. I’m sure if I had the organ, I’d have Peyronie’s. I assume I have Dupuytren’s Diathesis. I have just started taking COQ10.
I think that we all need to be cautious. It’s a chronic disease that is not well understood.
I’ll let you know how my COQ10 regimen goes.

Edited 03/23/2026 21:07