What a crock! Collengase is a pipe dream. Forget about it! Spend your time drinking or planning your next NA...still the champ!

This press relase could be interpreted in different ways, but I think it's still 99% hype. They're saying that additional Phase III trials are needed but they don't even have an adequate supply of the drug, so now they're announcing they'll invest in manuafacturing capacity.

jim,

I agree in that nothing means anything until we actually have an *active* funded Phase III program. On the plus side, the delay has allowed NA to begin to mature. I doubt Eaton would have picked up the charge if he had been using Collagenase regularly. In fact, what would be the big deal about NA at the ASSH convention if Collagenase had already become the new kid on the block? Surely CHS would think injecting some expensive high-tech material would be *far* more fun than scraping at Dups tissue with the end of a syringe :-)

In order for Auxilium to be able to sell their Pipeline Fantasy (as you claim it is), don't they *eventually* have to actually bring *something* to market and be profitable? Who would invest in a company without a track record of success? They can't just sell patches of Blue Sky forever.......can they? :-)

jim,

I can definitely see how your past experience would cause you to look at this with a jaundiced eye. What you describe is outrageous. Well, let's sit back and see:

"The company plans to initiate a second Phase III pivotal trial in Dupuytren's Contracture, during the second half of 2006."

If you're right, nothing will actually happen. That will not however, prove your are correct in their intent, but certainly will be in line with your assertion.

As a side note, one of the speakers on Eaton's ASSH team will be Lawrence C. Hurst of Stony Brook who wrote the Phase II study report: http://users.owt.com/watson/pages/pdf/collagen.pdf

That makes Hurst the leading expert in injectable Collagenase. (Apparently they have him fooled about their intent as well.) At the same time, Hurst is going to get an eyeful of Truth about NA, if he hasn't already. It would be fascinating to hear what comes of Eaton and Hurst sharing notes on what, at the end of the day, is almost the same procedure. Additionally, it will be interesting to see if Auxilium will continue to claim that it's product provides the *only* option to OS. That's part of their pitch. They certainly should know better after September.

jim,

Your last sentence. That's why in a head to head, with all the facts, risks and cost on the table (and our hands down with palms up)...........NA wins.

Such a bizarre thing to be able to say on a site funded by the inventors of Collegenase. Eaton has never been able to understand why BioS let us use this site to forever change his practice and possibly the course of Dups treatment history. For me the answer lies in all the current spam that surrounds this post------> They are asleep at the wheel. That does tell you something, though I'm not sure what. Again, we win either way. Thanks BioS!