Jerry, thanks for the link. When I started this group, I never expected the response. I'm grateful for the positive contributions that participantss like you have made.

There was an article from that link, "The Cause of Dupuytren’s Disease:  A New Theory!" which points to insulin as the "smoking gun" and lists related causative factors of DP that can affect insulin production. No 10 is worth a reprint for this forum.

10) Persons taking the glucoseamine/MSM/Condroitin complex have been anecdotally associated with DC:  Research has shown that glucoseamine can cause insulin resistance and infertility.  Furthermore, histologic findings have discovered that DC tissue samples contain a large amount of chondroitin sulphate, along with myofibroblasts, fibroblasts, type III collagen, and reducible cross-linkages.  This indicates that condroitin might be unsafe for those persons who are predisposed to developing DC.

It goes on further :
Due to the complex and not yet completely understood nature of insulin activity and insulin resistance in the human body, it is important to avoid simple solutions for a complex problem.  For example, even if it is true that more insulin can prevent DC, the consumption of additional glucose would not be helpful (to stimulate insulin production) because it could eventually lead to the onset of insulin resistance.  Conversely, injection of additional insulin would not be helpful because it could initiate a dangerous hypoglycemic condition.  The only way to maintain a healthy endocrine/insulin system is to maintain a healthy lifestyle, including a minimum of drinking, smoking, glucoseamine/MSM/Chondroitin, and coffee (conflicting studies are cited); coupled with sufficient exercise, sleep and a healthy diet.  A great deal of research is underway to better understand the mechanism of insulin resistance, so there is hope that a therapeutic treatment will eventually be found.

Best of luck with your recovery. I'm thinking you may have had some DC before taking the G/C, otherwise you went from zero DC to needing surgery in 90 days? That's just about unheard heard of. By the way, you apparently found this site recently. Did you find it *before* or *after* your surgery?

in re-reading about my dupuytrens disease I repeated right hand when I meant to describe my left hand where every finger is affected including nodes on my left wrist...

certainly wish I had found this site earlier..will be checking in now...also told msn is just as bad to take as g/c...if anyone is considering surgery please check with as many people as possible who have had sucessful surgery...I can only say I went to the best in New York and the best hospital and my hand was butchered...all the hand therapists I went to said the same thing..surgery rarely works and in most cases make the disease worse...for all who had sucessful surgery, that's great and for the rest...research carefully and check with Dr. Eaton first...good luck...

I find it amazing that I wrote to Jane Brody of the N.Y.Times, Prevention Magazine, Juvenon Health Letter and our local newspaper and no response...anyone tried contacting the tv news about this supplement and dupuytrens??