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10/29/2001 23:48
Neil Manceynot registered
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10/29/2001 23:48
Neil Manceynot registered
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Dr Hurst
I am a 29 Englishman I have suffered from DC since the age of 10 which make me the youngest recorded age in medical history. I have DC in both hands and both feet and the little finger on my right hand was amputated in 1997, the professor I see in London has mentioned the Collagenase trials and I was wondering if anyone knows Dr Hurst's email address as I would like to ask if any such trials are due to take place in this country.
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11/09/2001 23:19
crayton Bernernot registered
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11/09/2001 23:19
crayton Bernernot registered
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Stanford Trials?
Has anyone heard anything further about the trials at Stanford? My hand doctor yesterday told me to hold off surgery as long as possible. He thought, but who knows, that C might be available later next year...
thoughts/comments? I have it in both hands..3 operations on the left...2 on the right.. identical finger(5th) and I don't want to operate again
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11/09/2001 23:39
Gary Evansnot registered
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11/09/2001 23:39
Gary Evansnot registered
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collagenase
There seems to be a real absence of information about collagenase (at least I haven't found enough). Is it applicable to all degrees of contraction? How long can a person put off surgery while waiting for approval? Are there any updates on the timeline for approval by the FDA? I have surgery scheduled for the middle of January 2002, any suggestions? I have 90 degrees in little finger on one hand. The contraction took place in the last 16 months, previous to that had dermal pits for 5 years.
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11/10/2001 23:08
jimh 
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11/10/2001 23:08
jimh
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Collagenase Phase III Trials
Collagenase is supposed to enter Phase III trials "soon". My understanding is that real marketing and distribution wouldn't even begin until those trials are successfully completed. Detailed information is very hard to obtain.
I recently had surgery (my second) because the 5th finger had been progreesing rapidly and had reached 90 degrees. I'm pessimistically assuming that Collagenase won't be available for at least another year.
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11/28/2001 23:23
Clayton A. Peimer, MDnot registered
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11/28/2001 23:23
Clayton A. Peimer, MDnot registered
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Collagenase Phase III Trials
The study models are set by the FDA; and are going to be opened in 2002, likely 2nd quarter based on what has to be done at the four sites in the US that will accept patients.
To run the study one needs Institutional Review Board approval; a site visit from the FDA and also from the PI; and several other hoops that will take some time to do (I love government projects).
Anyway, I can tell you that we expect to thread all those regulatory needles to get the project going at Evanston Northwestern Orthopaedics. HOWEVER, please DO NOT CALL, WRITE or EMAIL until AFTER 31 January 2002 because we are NOT allowed to screen or to enroll anyone until and unless fully approved. Did I mention do not waste your time calling yet?
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08/03/2002 23:13
Alannot registered
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08/03/2002 23:13
Alannot registered
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Clinical Trials
For information about clinical trials ongoing in the United States, go to www.clinicaltrials.gov At that site when you enter Dupuytrens as the subject, two clinical trials are shown. Reading about these two trials, one could conclude that the subject is not axactly on fast track!
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08/05/2002 23:41
Pierre Pouliotnot registered
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08/05/2002 23:41
Pierre Pouliotnot registered
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Needle Aponevrotomy
Incredible as it may seem, no one in this forum has read or heard about needle aponevrotomy! If you have Dupuytren, do yourself a favor, go to the forums "Needle aponevrotomy", "www.dupuytren.org" or "Forum Dupuytren".
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08/05/2002 23:16
Gary Evansnot registered
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08/05/2002 23:16
Gary Evansnot registered
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Collagenase
Pierre,
We have been talking about NA for two years on this forum. I took the information from this forum to my surgeon about a year ago.
You are still sounding like a commercial. The important thing for you to do is the get some independent research numbers for us and put them on this forum. My surgeon was completely open to NA, but said the numbers just weren't there for him to change his procedures. My surgeon said cost of procedure had nothing to do with his reasoning.
Gary
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08/05/2002 23:43
Jannot registered
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08/05/2002 23:43
Jannot registered
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Pierre~sq~s ideas okay to be expressed
I, for one, do not think that Pierre is a commerical. I also don't think he should "get numbers" to prove anything. This forum is for exploring all ideas, not just those who claim to have the best surgeon and the most acquaintances who had surgury. Each patient is different. The needle may just be the right choice for some! One thing I have learned in this forum is to ignore Gary's commericals for surgury.
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08/05/2002 23:48
Gary Evansnot registered
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08/05/2002 23:48
Gary Evansnot registered
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Collagenase
Jan,
Excuse me for offending you. I just thought Pierre's statement that, "Incredible as it may seem, no one in this forum has read or heard about needle apronevrotomy", was a little misleading. It has nothing to do with having surgery or not. I could care less if anyone chooses surgery or not. I am certainly not promoting it(surgery) or a surgeon. I gave careful consideration of NA over a year ago, before having my surgery. It just wasn't for me because the contraction in my finger was too far a long.
I am not going to ignore unbiased clinical test results concerning recurrence and appreciate all of the information available.
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