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Collagenase phase III
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10/08/2003 23:59
tom

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10/08/2003 23:59
tom

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Thanks Randy

Randy, thank you for your well thought out posting and for letting us know the result of contacting Betsy's doctor.

I hope you are right in that the idea that doctors in the US can be swayed to learn NA. I can't help but believe that they will not until they lose enough business.

10/08/2003 23:44
Stage One

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10/08/2003 23:44
Stage One

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Steve H~sq~s nodules

Hi, I am curious about "who" told you that the size and
location of your nodules may have ruled out NA. Was it a
U.S. Doctor or a consultant in Europe? Follow your own instincts; the rest of us appreciate insights. I am not asking for specific names or locations, just the country.
(If an M.D. in Tulsa says, "No;" it might have a different
conotation than if said by a Dr. in Geneva, or Paris.)
good luck, whatever you decide to do.

10/12/2003 23:27
steve h

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10/12/2003 23:27
steve h

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doctor was in oklahoma

He is recognized as the best one in town. He has seen NA when he was a resident 30 years ago. He just said he would never cut into someone's hand because of the afore mentioned risks. He is not pushing surgery either. He has plenty of money and appears very ethical. Watching these boards people seem to be happy with NA. Has anyone had a bad experience with it??

10/12/2003 23:12
Wavey

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10/12/2003 23:12
Wavey

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Biospecifics going belly up

Biospecifics is going belly up? Really?

10/12/2003 23:48
Anon Emus

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10/12/2003 23:48
Anon Emus

not registered

APO

Steve,

NA wasn't available 30 years ago, therefore you have me utterly confused as to the procedure of which your physician refers?

Besides; NA is NOT of any benefit on a nodule; NA corrects bending of fingers beyond at least 20 degrees.

I personally am not aware of any nerve or tendon damage due to an APO procedure.

09/08/2004 23:57
Patsy 
09/08/2004 23:57
Patsy 
Phase II

Is there now money for phase III trials to resume? Do we know how long the trials will last before the product is available for us?

09/09/2004 23:02
chad reese

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09/09/2004 23:02
chad reese

not registered

Collagenase

I THINK A LARGE SCALE INVESTMENT IN BIOSPECIFICS BY DUPUYTREN'S PATIENTS IS A FEASIBLE IDEA.

It's the kind of thing that is now possible due to internet, forums, etc. I am not a business expert (I am a physician), but I would think there would be a mechanism whereby thousands of patients could chip in money as an investment in a sort of "class action" investment model. Each investor would have a chance of making money from it in the future. The beauty is, if the phase III trials go through and are as succesful as the phase I and II, then it would probably be a cinch to get more money (if it were even needed at that point) by industry investors to go to market with the collagenase product. FDA approval and marketing are not as far away as some in this forum think. It would be a crying shame if Biospecifics ran out of money at this point in the game. The benefits of having an additional type of treatment, in addition to NA, available to us are enormous. Likely, some patients will respond to one but not the other. It increases all of our chances of getting through life with hand function if we have multiple non-surgical options.

If this dies due to lack of interest, it will be our fault. Nobody cares about Dupuytren's disease except us, and the few who could profit from it. I think we need to partner with them, not just see them as "us" and "them."

By way of disclaimer, I have no financial interest in Biospecifics or anything to do with Dupuytrens or anything related. My interest is as a person who works with his hands, loves his job, and has early disease.

09/09/2004 23:20
Charlie 
09/09/2004 23:20
Charlie 
Investment

I am interested. What investment vehicle do you propose? A special stock offering? Are we talking hundreds or thousands?

09/09/2004 23:52
chad reese

not registered

09/09/2004 23:52
chad reese

not registered

collagenase investment

I am getting some profesional advice on how this could be done, since my business background is not strong enough for me to do it myself. So I don't have the answers yet.

As far as amounts, I would hope that it can be done in a way that the amount could be small or large, depending on the individual's resources. I hope to find a very wealthy person or 2 who are worried about the future of their hands. But a lot of money could come from a large number of people with average resources willing to invest relatively small amounts of money.

09/09/2004 23:19
Steve

not registered

09/09/2004 23:19
Steve

not registered

hold on...

folks, Biospecifics has licensed the use and development to another company called Auxilium who has the resources and plans to restart Phase III trials soon (I hear Jan or Feb). Read their S-4 prospectus and buried in it are the details of the deal...ticker is AUXL. I think Yahoo can get SEC forms like this. Help is on the way...no need to pass the hat.

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