I think the second "u" is silent like the
"p' in swimming !

Dear Father Time,

There is no such thing as Time! Time is an illusion! The correct pronunciation of "Dupuytren's" is a perennial problem. I am not a native speaker of French, but I have been learning the language for 42 years, have visited France several times, and lived and worked there for 6 months, so I have a fair idea of how it should sound. More than that, I have before me an excellent dictionary of French pronunciation written by a Frenchman! So, for those who are interested, here is the full definitive description of how to say it:

Both "u"s in "Dupuytren" are sounded. It is the thin sort of "u", where your tongue says "ee" but your lips say "oo". The second "u" is rapidly pronounced, so that the syllable sounds like "pwee". The three syllables "Du-puy-tren" have equal weight and length. Despite the view expressed by one of the earlier posters, there is no accent on the second syllable; if there is an accent anywhere it is on "tren". If you know how to pronounce the French words "vin blanc" (white wine), which sounds a bit like "vang blong", Dupuytren rhymes with "vin" rather than with "blanc".