?Current Collagenase Approval Status? |
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08/05/2005 23:15
Bobnot registered
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08/05/2005 23:15
Bobnot registered
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Re: collagenase status
So what's "orphan drug status"?
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08/06/2005 23:20
Wolfgang Wachnot registered
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08/06/2005 23:20
Wolfgang Wachnot registered
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Re: collagenase status
As far as I know the collagenase therapy is currently in the so-called phase II of the FDA approval. In this phase a larger number of patients is treated in various hospitals all over the country. Patients can apply to participate in this study. So far results of this treatment have been very promising.
I am participating in Dupuytren Society which informs on the status of various therapies under www.dupuytren-online.info. Injection of collagenase, if FDA approved, has the potential to become the best treatment of late stages of Dupuytren's disease where fingers are already bent.
Wolfgang
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11/08/2005 23:43
Hammer headnot registered
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11/08/2005 23:43
Hammer headnot registered
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AA4500
In August 2005, Auxilium signed an agreement with Cobra Biologics Ltd.for the further development of the manufacturing process, scale up and manufacture of clinical supplies for AA4500 for both Peyronie's and Dupuytren's Diseases.
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12/19/2005 23:26
Larry
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12/19/2005 23:26
Larry
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what about Dupuytrens?
yeah but RandyH, they said nothing about how it's working for DC?.....
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12/19/2005 23:52
Randy H. not registered
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12/19/2005 23:52
Randy H. not registered
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Hopeful
I just got off the phone with an executive at Auxilium who told me that they definitely do have plans to continue with the trials "definitely next year". However, confidentially agreements prevented him going into specifics. Unfortunately, this is what I was told six months ago or so.
The press release below would indicate that Auxilium does indeed have plans for Collagenase, as they just invested more money into expanded rights, specifically for Frozen Shoulder applications.
One of the reasons this forum was created in 1999 was to promote Collagenase. At least it's been put to good use ever since.
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12/19/2005 23:01
SusieQ
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12/19/2005 23:01
SusieQ
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Hopeful
I've read on other threads that Frozen Shoulder is common amongst Dups sufferers, and that near half of those with Frozen Shoulder also have dups!
How the body handles collagen seems to create the connection.
If my memory serves me well, I read on frrozenshoulder.com that there is a fold which unfolds to allow the arm to stretch upward in side-extended position. Collagen gradually makes the inner sides of the fold stick together restricting certain movements. And the process of freezing takes place over a period of time; then the shoulder stays frozen for a time; and then gradually will start to thaw!
I had what was finally diagnosed as frozen shoulder (left shoulder) maybe 12 years ago.
A few months after beginning Dups. symptoms appeared early this year, my right shoulder started the freezing process, too. It's not pleasant but I find ways to deal with it so its not a major disability.
The fact that Auxillium is undergoing trials for Frozen Shoulder (though quote in previous post doesn't state known positive results as yet) MAY be a hopeful sign that Auxillium now has more to "protect" and may more aggressively begin more collegenase studies for various applications!
Let's Hope So!!!!
Susan
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