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Imiquimod: A new treatment?
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05/12/06 02:54
Graeme

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05/12/06 02:54
Graeme

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Dr Denkler

thank you Keith for your interest and helpful background information. I've had many operations on my left foot then no more growths after a fascia excision. My surgeon explained to me the skin/fascia connection with fibromatoses.
Dr Lermusiaux has replied and has expressing his interest and is investigating Imiquimod.

05/12/06 02:22
Frances

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05/12/06 02:22
Frances

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Research

Would this be good for Peyronies?

05/12/06 02:23
Larry Berryman

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05/12/06 02:23
Larry Berryman

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Research

The more I read about this drug, the more I believe it has potential in treatment of Dupuytren's. The mode of action of the drug should counteract the production of the fibroblasts, and may even reduce the size of the cords and the nodules. I hope a drug company will pick up on this and do some controlled studies....we have suffered enough.
The collagenase has less potential, in my opinion, because it will still have to be injected and whenever you have to inject a drug....there is a much greater risk of potential serious side effects. I am so happy that many of you out there are helping us get the word out about this potential treatment!!

05/13/06 02:05
Frances

not registered

05/13/06 02:05
Frances

not registered

Imiquimod

Thanks all for bringing this information to our attention and having the backbone to give it a try. I posted earlier that I wondered if it would be good for peyronies but I also wonder if it would help ledderhose as well. Maybe some day this will all be figured out.

Take care for now and God Bless,

Frances

05/13/06 02:26
jimh 
05/13/06 02:26
jimh 
Imiquimod

Dupuytren's, Peyronie's and Lederhose are virtually the same condition in different parts of the body. Collectively they're someties referred to as 'superficial fibromatoses'. What works for one should work for all.

05/13/06 02:31
Graeme

not registered

05/13/06 02:31
Graeme

not registered

Imiquimod

Hi Frances thanks for your encouragement.
You question imiquimods possibilies with Ledderhose I also have Ledderhose and are applying the cream to my foot nodule. I wonder how this will go as the nodule is years old and is very large. But it's worth a try.

05/15/06 02:22
Randy H.

not registered

05/15/06 02:22
Randy H.

not registered

Aldara.com

Larry,

While a controlled study of the off label use of Imiquimod would be nice, it certainly is not required if a high percentage of patients report significantly positive results. There are a lot of drugs that are prescribed "off label" for conditions unrelated to the treatment it was approved for. Some uses are backed by published clinical studies of effectiveness, other are not. All that's needed is a doctor that believes a medication could be of value to a particular patient. Some MD's are more conservative, needing to see published studies, others will go with what they hear from colleagues.

Right now there aren't any studies on Imiquimod for Dups. And unless we have people willing to step up and try it, there *never* will be. I say bully for those who can get their hands on this (or should I say "get it on their hands") and give it a go. I would like to be among them.

3M happens to own this medication under the name Aldara. (see Aldara.com). The safety profile looks good. All the FDA found was skin irritation.

05/16/06 02:00
Dr Larry Berryman

not registered

05/16/06 02:00
Dr Larry Berryman

not registered

imiquimod treatment

I have been using the Imiquimod (Aldara) now for 7 days post NA surgery....there has been no topical skin irritation, or redness. Of course it is too early to ascertain any improvement, but at least I am not reacting adversely as of yet.

I wonder what would happen if DMSO was applied after the Aldara cream?

05/16/06 02:01
Randy H.

not registered

05/16/06 02:01
Randy H.

not registered

?????

Larry,

How are you covering the cream so you don't rub it off at night while sleeping?

05/16/06 02:16
Graeme

not registered

05/16/06 02:16
Graeme

not registered

Aldara

Randy

Good question. 3m instructs that the area applied is not to be covered or gloved etc.
Shortly after application the Aldara sort of "sets" in a glistening firm state. It looks like a snails trail and does not rub off very easily.

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Kenalog   improvement   surgery   Acretyl-L-Carnitine   section=News&id=1226536   treatment   Dupuytren   prostaglandin-E2   prescription   prostaglandin-F2   application   applying   Reconstructive   potential   effects   Imiquimod   differentiating   Ledderhose   Lermusiaux   scientifically