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Collagenase - where is it available?
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09/13/07 17:57
moondanc 
09/13/07 17:57
moondanc 
Re: Collagenase - where is it available?

The link below gives information on Phase III clinical trials of Clostridial Colllagenase for Injection (AA4500) with dates, locations, etc. They started in August, 2007 and locations in 7 states -- a little more than half of the total state locations-- are currently recruiting. Conducted by Auxilium Pharmaceuticals.


http://www.clinicaltrials.gov/ct/show/NCT00528606?order=2”



09/14/07 02:53
homeboymi 
09/14/07 02:53
homeboymi 

Re: Collagenase - where is it available?

Thank you for your answers. I jumped the gun when I posted prior post. I am not eligible for this trial.
My fingers are not bent. After reading other posts on this forum, it seems I am at the stage where one seeks radiation. Thank you again, it is nice to know there are people out there who are ready and willing to share their information with me.

Gary

09/14/07 05:33
bstenman 
09/14/07 05:33
bstenman 
Re: Collagenase - where is it available?

The article shows most potential sites are not registering trial participants. When I spoke with the people at Stanford earlier in the year they told me that the people who had not been selected for the Phase II trial would be first in line for the Phase III trial whenever it began.

With 217 participants for all the clinics shown there is clearly still a problem with production of the collagenase in quantity. As this is a double blind placebo trial there will only be half of the 217 getting the true collagenase in their injections. So they have sufficient amounts to treat roughly 110 people total over the course of the next 6-12 months. So I still believe it is 2-3 years away from being readily available to anyone desiring this form of treatment.

10/25/07 01:01
bshatzer 
10/25/07 01:01
bshatzer 
Re: Collagenase - where is it available?

The double blind study will administer Xiaflex/placebo in a 2:1 ratio - in other words, two thirds of the participants will receive the actual drug and only one-third the placebo. Those given the placebo will be eligible for a follow-up open label study in which everyone will receive Xiaflex.

There is a separate, somewhat larger, open label study which will be conducted concurrently in which all participants will receive the actual drug.

I've been preliminarily accepted for one of the studies though I don't know which one as of yet. I'm scheduled to go in for the preliminary physical and medical exam on November 8. Assuming I pass and am formally accepted, I'll post my experiences and results.

I was -really- dreading surgery and the nearest NA physician is 300 miles away. This certainly looks like the preferable alternative.

03/05/08 17:32
sven1419

not registered

03/05/08 17:32
sven1419

not registered

Re: Collagenase - where is it available?

Research Trials Collagenase injection treatment for Dupuytrens.
I have just commenced Collagenase research treatment in England. injection Monday 3rd March and the cord broken successfully Tuesday 4th March.
Continuing treatment to other fingers over the next 9 months

03/05/08 17:44
wolfgang

not registered

03/05/08 17:44
wolfgang

not registered

Re: Collagenase - where is it available?

Congratulation Sven! Where did you get your collagenase?

Wolfgang

03/05/08 18:20
JulieH 
03/05/08 18:20
JulieH 
Re: Collagenase - where is it available?

This is great news, being from England originally, going home for this treatment would be a great option. Can you give more information on where this was available?

03/05/08 20:10
bstenman 
03/05/08 20:10
bstenman 
Re: Collagenase - where is it available?

Long term this will probably be a superior treatment to NA. NA involves only incisions in the tissue so it has limited benefits in terms of total flexibility and use of the hand. The collagenase injection should be able to travel to surrounding tissue and provide both greater loosening initially and a longer interval between treatments.

I would still bet that it will not be available to the general public until 2010 as the manufacturer needs to be able to produce the product in quantity which has been the principal stumbling block for many years.

03/05/08 20:14
bstenman 
03/05/08 20:14
bstenman 
9 months?

Hi Sven,

It just struck me that you mentioned treatment over a 9-month period. How often do you have to go and receive injections and did they explain why the 9 month treatment period?

With NA there is a single surgical session. With X-ray therapy there are two sets of week long treatments six months apart. So I am curious as to the number of visits one would need to make to a clinic to receive the injections as this could have a big impact on the overall cost involved.

Thanks,
Bruce

03/05/08 20:55
Randy_H 

Moderator

03/05/08 20:55
Randy_H 

Moderator

Collagenase Vs NA

Collegenase will also be *far* more expensive than NA. Most MCP corrections are quite simple and NA should do as good a job as Collegenase. It's the PIP where Collegenase may prove to shine over NA.

I'd like to see NA far more accepted than it is today before Collegenase hits the road. The marketing to the CHSs will be extensive and those not trained in NA by that time never will be. They'll just take the easy route and use the far more expensive Collegenase. It will be one more example of unnecessary medical cost.

I'd love to see a long term study pitting NA against Collegenase. That would be fascinating. However I can't think of an economic incentive to do it. No one makes money off NA except the practitioner and such a study would be the *last* thing the owners of Collegenase would want to see happen.

In the end it will be the NA experts like Denkler who will use both and then be able to tell us of the comparative strengths and weaknesses through their experiences.

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interphalangeal   treatment   Contracture   metacarpophalangeal   Collagenase   injection   Xiaflex   Patients   1212&highlight=   double-blind   clinical   injections   fingers   surgery   Collegenase   available   participants   Dupuytren   Pharmaceuticals   placebo-controlled