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life expectancy
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06/14/2004 23:35
beth

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06/14/2004 23:35
beth

not registered

life expectancy

I heard that poeple who suffer from Dupuytren's have a shorter than normal life expectancy (I have no idea why this might be or if it is even true), does anyone know anything about this?

06/14/2004 23:23
anon

not registered

06/14/2004 23:23
anon

not registered

life expectancy

I know I've taken a few years off my life just stressing out about it...but seriously, there are some studies in the Nordic countries that show this to be true in those studies. Who knows why...its a disease where diabetics and alcoholics get it more frequently and they live shorter lives too but I would have thought the studies would control for this factor.

06/14/2004 23:35
JERRY 
06/14/2004 23:35
JERRY 
Mortality

There have been NO decisive studies that confirm that alcoholics, diabetics or epiletics have more incidences then others where D/C is concerned. I thought we put that agenda to bed a long time ago.

You can make a case for any ailment to connect it with D/C, but the truth is that since Dupuytren's runs the gamut throughout most descendants of European ancestry it is evident alongside any condition.

06/14/2004 23:14
Sean 
06/14/2004 23:14
Sean 
Mortality

At the Depatment of Hand Surgery, University Hospital, Uppsala, Sweden between 1965 and 1996, a study observing 16,517 in-patients discharged from the hospital after surgery for DC. There were 7,579 deaths in the group during the 30 years of observation. The expected number of deaths was 7,132. "We observed a significant increase in overall mortality for both genders in all age groups except in patients under 20 years of age, in women between 30 and 39 years of age, and among patients over the age of 70 at the time of surgery. The increased risk was as high as 67% among men in the age group 30 - 49 years, and in women the risk was more than doubled if they underwent surgery for DC before the age of 50. Analysing the overall increase in mortality according to the time since surgery for DC revealed no increase in risk up to 5 years after surgery. However, a clear increase in mortality was noted 5 - 9 years after surgery (8%), 10 - 14 years after surgery (13%), and >15 years after surgery (26%).
Cancer was the second most common cause of death (25%) with a significantly increased overall mortality of 20%."

"There was a significantly increased risk for buccal, oesophageal, gastric, lung and pancreatic cancers, which indicates that smoking and alcohol abuse are probable risk factors for DC."

The 53 page summary of the study can be found on the web.

06/15/2004 23:11
Stage One

not registered

06/15/2004 23:11
Stage One

not registered

Correlations

Sean, might one infer that DC Surgery and morbidity
are asssociated? Perhaps DC sufferers like (Irish) Ronald Reagan live to be 93 years old Alzheimer patients because they never had "DC surgery." I have no agenda, I just wonder
if the Swedes that accept surgery are statistically
equivalent to the Swedes who did not have surgery, (or went
to Paris instead.) Are you aware of similar studies elsewhere? Denmark seems fertile ground for DC concerns.
The incidence is relatively high there. Was suicide a factor? Does anyone else have knowledge of DC studies
(about any aspect of population correlations.) Thanks.

06/15/2004 23:30
John

not registered

06/15/2004 23:30
John

not registered

DC

I'm sure that if they would have had NA instead of surgery that their life would have been prolonged considerably.

06/16/2004 23:40
kim

not registered

06/16/2004 23:40
kim

not registered

re: Reagan

I think Reagan did have D.C. surgery of some sort. The surgeon who first diagnosed me was at Bethesda at the time he had it done and said it was a relief to him that he wasn't the one doing it. Also looking at pictures of him, sometimes one can see that he has a splint on his left hand, ring finger I think, which one typically has following surgery.

06/16/2004 23:33
Anon

not registered

06/16/2004 23:33
Anon

not registered

Ronald Reagan & Margaret Thatcher

Both had hand surgery see;

http://www.surgerydoor.co.uk/so/detail2.asp?level2=Dupuytrens%20Contracture%20-%20Partial%20Fasciectomy

06/16/2004 23:11
Anon

not registered

06/16/2004 23:11
Anon

not registered

Donald Rumsfeld

Saw him with the old familiar curved pinky then handsplint,
betcha he has/had it too.

Anon

06/23/2004 23:30
Randy

not registered

06/23/2004 23:30
Randy

not registered

Dupuytrens & alcohol/smoking

If you read the articles about life expectancy, one conclusion reached by the authors is that the same **behaviors** may be correlated with both Dups and early death: i.e.: smoking and alcohol abuse. Both are known to create free radicals, so they may both independently contribute to Dups and cancer in the same way. It may simply be that among Dups sufferers there are a larger than normal percentage of smokers and alcoholics, because those may help trigger Dups in genetically prone individuals. This may be enough to explain the statistical correlation between Dups and life expectancy.

Therefore, it may be inferred, that if you don't smoke, and aren't an alcoholic, there may be no connection between your case of Dups and your untimely (early) demise whatsoever. It's the smoking and alcohol abuse that always have that correlation, not the Dups in itself. Correlation does not prove causation.


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