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01/16/2005 23:14
The observer

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01/16/2005 23:14
The observer

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Dr. Bing Siang Gan has been recognized by the Institute of Musculoskeletal Heath and Arthritis (IMHA) for his work with DC at the Lawson Health Research Institute in London Ontario.

In an article by Julia Capaldi (July 2004) she writes that Gan has been 'studying the molecular and cellular mechanisms of DC and have identified specific molecules that may be responsible for the disease process. They are currently investigating whether manipulation of these molecules may alter the characteristics of the disease'

She quotes Dr. Cyril Frank the IMHA's scientific director, ' Studies such as Dr. Gan's are important because they result in better understanding of the gentic and enviornmental causes of disease, as well as optimal methods of treatment to eliminate pain and disability'

Dr. Gan hopes his study will eventually lead to the development of alternative methods of diagnosis and treatment of Dupuytren's contracture, and possibly other close disorders such as desmoid tumors, hypertrophic scars and abnormal wound healing.

For further information google his name Dr. Bing Siang Gan

The observer

01/16/2005 23:20
Randy H.

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01/16/2005 23:20
Randy H.

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Looking at the info a little closer

Observer: Thanks for the Observation! We need to keeps tabs on this.

Here is the direct link: http://www.cihr-irsc.gc.ca/e/22774.html

This is a report on cutting edge research into the chemistry behind Dups. So, else what do they say?

"Currently, the only *accepted* treatment for Dupuytren's contracture is surgical resection of the affected tissues, followed by prolonged post-operative rehabilitation."

By using the word *accepted*, the above statement is (sadly) mostly accurate. Had the author used "only proven" or "only effective" it would not be.

01/16/2005 23:37
The observer

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01/16/2005 23:37
The observer

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Looking at the info a little closer

Thanks for the link Randy but I was not able to reach it that way so I

1. googled 'Canadian institute of health research' then once on the website home page,

2. clicked 'musculosceletal health and arthritis under the the 'find and institute' bar then,

3. found the search function on that page (bottom left of screen) then typed in 'dupuytren's contracture'

Presto, the info came up.

The observer

01/16/2005 23:50
The Observer

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01/16/2005 23:50
The Observer

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The individual

If you wish to see a picture of the esteemed Dr Gan you can do so by googling 'The Lawson Health Research institute' then use their search function (way upper right) to find personel search function (top) where you can type in his name and see his info.

Who knows, maybe this is the face of someone who can give us some answers someday in the future....or have some decent research started for the next generation to continue.

The observer

01/17/2005 23:33
observer

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01/17/2005 23:33
observer

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other research

Google 'clinical trials dupuytren's contracture'. This brings up other research that is going on around the world that is listed on the net.

Don't know why I didn't think of this before. It's a useful way to search to keep updated.


01/17/2005 23:41
observer

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01/17/2005 23:41
observer

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Mild Duypuytren Disease: get non surgical treatment

reversing the order also works 'dupuytren's contracture clinical trials'.

05/25/2006 23:26
larry mills

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05/25/2006 23:26
larry mills

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Mild Duypuytren Disease: get non surgical treatment

I am in contact with Spanish speaking doctor who want to treat patient with mild case of Duypuytren Disease using (1) non proven suggestions from Dr Bing Siang Gan's team, or other techniques such as injectable form of the enzyme sometimes called AA4500 Cordase? Collagenase Santyl??

05/25/2006 23:17
jim h

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05/25/2006 23:17
jim h

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collagenase????

AA4500 is not publicly available and is not likely to be available for a long time.

I've read something about Dr. Bin Siang Gan's work but was not aware he had proposed any treatment.

08/16/2006 23:55
DC

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08/16/2006 23:55
DC

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collagenase????

I would like to see what adverse affects collagenase will have on surrounding areas in the hand. Collagenase is powerful stuff and could destroy cells in the process.

08/17/2006 23:59
Randy H.

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08/17/2006 23:59
Randy H.

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Got Some Spare Cash?

DC,

The FDA has the same question you do. So far in Phase I and II trials, Collagenase has had no reported negative side effects. It effected only the diseased Dups collagen. Only a small portion was injected into cords to disrupt them. They were then snapped in the same way NA allows for the breaking of cords.

The problem is that each session of trials requires *more* subjects and cost more *money* to perform. Phase III is the final trial to show the FDA that it is both "safe and effective". I happen to know that they were in final negotiations for a trial site at UCLA, but pulled back because of lack of funds. That was over three years ago.

It is a shame that the final proven answer to your question may never come.

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investigating   Collagenase   Institute   Musculoskeletal   understanding   post-operative   Dupuytren   musculosceletal   manipulation   characteristics   disease   hypertrophic   Duypuytren   contracture   enviornmental   observer   rehabilitation   Research   treatment   negotiations