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is it risky?
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08/28/04 02:38
David L

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08/28/04 02:38
David L

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is it risky?

My hand surgeon told me that he thought collagenase would be risky since it dissolves collagen and both dupuytren AND tendons are made of collagen. So he is worried it could damage/dissolve tendons that the drug may come in contact with. Anyone know the science here to refute this or has someone been in the phase II trial already? Or maybe someone from Stonybrook or Biospecifics?

08/28/04 02:44
Frances

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08/28/04 02:44
Frances

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Comment without knowledge

It's a shame your doctor made those comments. The studies are for that exact purpose...to study/answer any questions regarding the drug. Wait with an open mind until the results are in. Many of us heard negative comments about NA from our doctors/surgeons when in fact they knew nothing about it. Terribly unfair to poo-poo something you don't know anything about - as was done in your situation.

Frances

08/28/04 02:45
jjim h

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08/28/04 02:45
jjim h

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the Question

Normally I wouldn't cast doubt on the expert opinion of a surgeon but that comment just seems strange to me.

If you want to talk about a treatment that has risks - it's surgery, as I can tell you after having one on each hand. Things go wrong, tissue and nerves are damaged, various sorts of deterioration and atrophy can occur in the years that follow.

The idea with collagenase is not to inject enough to completely dissolve the band - just weaken it enough that it can be snapped.

Sure there's a risk, but the question is - how does the risk compare with that of surgery?

BTW these questions are probably moot as I now doubt collagenase will ever be available for Dupuytren's. The rights have been sold to another company (Auxilium) that seems only interested in marketing it for Peyronie's.



08/28/04 02:52
Steve

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08/28/04 02:52
Steve

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the Question

Jim,

If you have seen other places, the trials for collagenase are beginning soon again. Auxilium is funding both the peyronies and dupytren indications for collagenase if you read their prospectus from their recent IPO (ticker AUXL). I have been told that they will be moving forward in January or February for the trial and are getting the patients lined up as we speak.

08/28/04 02:11
jim h

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08/28/04 02:11
jim h

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the Question

That's good news.

I guess I've gotten cynical about the "product pipeline" thing. It seems like a company will buy the rights to new products, then just use them as a honey pot to attract investment - which turns executive salaries and bonuses.

I hope Auxilium is different.

08/29/04 02:01
Frances

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08/29/04 02:01
Frances

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the Question

I hope collegenase will become available....we need all the options we can get.

Frances

08/30/04 02:06
Terry

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08/30/04 02:06
Terry

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the Question

My Othopedist (who has done lots of surgeries)is very positive about the Collagenase treatment--and, in fact, strongly recommended I hold off surgery awaiting FDA approval--or that Stanford expand their test group to include more. He is located in San Francisco, so knows the Stanford doctors involved in testing. I have an appointment with him in a couple weeks, so should know more about what is going on with the Stanford test. Meanwhile, I made an appointment with Dr. Eaton the end of September since I have more confidence in NA than in surgery, and can't wait for the slow wheels of FDA to approve new methodology.

08/30/04 02:39
Alan

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08/30/04 02:39
Alan

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the Question

Good for YOU Terry!

Have you shown your Ortho the Hand Clinic Site and asked for an opinion regarding the far less intrusive NA? By the time the FDA gets around to approval of anything in this area, we will perhaps ALL be to old too care!!

Good luck in your scheduled NA with Dr. Eaton. He is a GEM and the treatment is relatively painless!

An OldCdog

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Othopedist   treatment--and   recommended   Stanford   confidence   relatively   available   indications   Biospecifics   approval--or   treatment   appointment   completely   collagenase   methodology   Auxilium   deterioration   collegenase   surgery   Question