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The Cause of Dupuytren’s Disease: A New Theory!
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11/22/04 01:20
Nypon 
11/22/04 01:20
Nypon 
Vit. D

Kevin misrepresented what I wrote. I did not say anything like "I can't possibly be deficient in vitamin D because I live in California", as you will see if you read my post. The sun is only one of several sources from which I get vitamin D.

11/24/04 01:28
Bigk200

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11/24/04 01:28
Bigk200

not registered

Vit. D

Mr. Nypon,

In my previous post, I concluded that you are probably not deficient in vitamin D. So I think we are on the same page!

11/28/04 01:05
lwhite

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11/28/04 01:05
lwhite

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Dupuytren~sq~s Disease

I just returned from my doctor and was told I have Dupuytren's Disease in my right hand. I have had the
small lump and the dimple for approx. 3months. I was also
told it was genetic, however, no one else in my family, to
my knowledge has the Disease. I do a lot of yard work and
thought it was just another callous. Could there be a connection?

12/02/04 01:09
Bigk200

not registered

12/02/04 01:09
Bigk200

not registered

yard work

From what I have read and experienced personally, I do not believe that yard work and manual labor will cause Dupuytren's, but it can be a co-factor. In other words, for someone who is not predisposed to getting Dupuytren's, that person could do yard work forever without ever developing Dupuytren's, but for the person who is predisposed, that person will probably get the Dupuytren's sooner than if he/she had never done the yard work.

As for those persons who are predisposed to getting the disease, I beleive that it is a combination of a genetic predisposition, coupled with some other external problem with their personal health, due in part to some failure in their endocrine system, or a poor diet of vitamins and minerals, or a poor lifestyle, or a combination of all three.

12/02/04 01:44
Tommy

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12/02/04 01:44
Tommy

not registered

golf injury

I believe that my DC in my left hand was triggered by a golf injury. It only took one "fat shot" when my 3 wood hit the hard ground before the ball. I let out a yell that could have been heard across the golf course. I couldn't continue playing that day, in fact, I had to give up golf completely. The invisible pain was (and still is) on the back of my left hand. The surgeon said that he would not risk operating. About a year later I saw this wrinkle forming in the palm of my left hand under the ring and little finger. Hello DC. The same hand surgeon said that I have my Celtic blood to thank or blame. He never suggested that the golf injury triggered the DC but I feel that's it's hardly a coincidence. I have a Feb. 05 appointment with Dr. Eaton.

Humor me for a few lines, folks. About four years ago I wondered if I could swing a golf club left handed (standing on the right side of the ball). I found that I could with no pain. So far I've shot a low round of 82 and plan to soon be one of the few golfers who has ever broken 80 from both side of the ball.

05/17/05 02:18
Steve

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05/17/05 02:18
Steve

not registered

Watch what you eat....

Here's that link again, lots of information that rings true to me. I've had Duputren's since '99, NA with Dr. Eaton in May '04, and I'll need to visit Charlie again this year because of a strong recurrance. Diet and adequate sleep are no doubt important factors in the preservation of one's health; how can these variables NOT have an effect on controlling, or perhaps eliminating Dupuytren's? Admittedly, I was a walking lab experiment in vitamin and nutritional supplements until about five years ago when I discovered ridges on my right palm. In addition to a potent vitamin regimin, I was taking glucosamine/condroitin (Move-Free), as well as DHEA and creatine, while spending 1-2 hours/4 days a week in the weight room. Nothing but a daily multi-vitamin now. Also, I notice that after drinking alcohol, enough to feel inebriated, 4-5 cocktails perhaps, that my fingers seem stiffer and slightly more curled the next several days than before the party. Stretching and hot water helps. Kevin's site and other anecdotal evidence one can find on the internet suggest that diet IS an integral factor in checking the proliferation of Dups, if not the cause.

http://www.dupuytrens-a-new-theory.com/pages/1/index.htm

05/18/05 02:12
Andrew 
05/18/05 02:12
Andrew 
Kevin~sq~s theory

At last, someone else who takes the sensible line! Kevin's website is excellent, though his contention that Dupuytren's is caused by a *shortage* of insulin needs to be taken with a pinch of salt. The evidence he gives does not seem to support such an idea, and it seems more likely that the reverse is true, if anything.

09/06/05 02:45
Frank

not registered

09/06/05 02:45
Frank

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Kevin~sq~s theory

This is just a start, believe me, but Kevin is doing what very few people, researchers, or particularly physician's ever do. He is putting pieces of this puzzle together. I will be writing to Kevin directly, but let me tell everybody now- the answer to many, if not all "collagen-build-up" (my term) disorders MAY be in the "ACTIVE" form of vitamin D-calcitriol. Your kidneys and liver make this from oral or sunshine-derived vitamin D. There are papers out there now showing that giving this "active" form of vitamin D to patients (careful-it can be very toxic) can stop and reverse collagen fibrotic diseases. That's what I'll say for now, but I would have not even looked at this if it weren't for Kevin. God bless you.

09/08/05 02:02
Begd

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09/08/05 02:02
Begd

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Papers

Can you point to some of those papers? hat is interesting

09/08/05 02:29
Frank

not registered

09/08/05 02:29
Frank

not registered

Papers

Send me an email, and I will send them to you. Some are abstracts, but I have one in particular where the patient was essentially cured of a desmoid (that's what I have, along with Dupuytren's), with calcitriol. I COULD be wrong, but I just wonder if all of these collagen-related fibrotic diseases to have enough biochemistry in common for this drug to work for many.

I'll put the abstract links here, but I've worked in healthcare for 23 years, and it seems lately that there's a ton of research on vitamin D, both the "inactive" and "active" forms, mostly for cancer (breast, prostate, lung, etc.). By the way, two of these papers are free for download. And it does not mean that someone has to be "deficient" in vitamin D in order for calcitriol to work. It actually seems to have a collagen-degradation activity.

Links:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15371466&query_hl=1

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15607567&query_hl=3

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10926872&query_hl=7

Hope this helps.

Frank

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anti-proliferative   Dupuytren~sq~s   Dupuytren   uids=10926872&query   peyroniesforum   uids=15607567&query   radiation   hypoglycemia   collagen-degradation   collagen-build-up   collagen-related   cmd=Retrieve&db=pubmed&dopt=Abstract&list   sunshine-derived   VitaminDIntoxification   predisposed   dupuytrens-a-new-theory   vitamin   uids=15371466&query   part-convincing   Disease