After my quick progression this year to 45 degrees and 2 NA surgeries on the same cord, I previously reported that taking colchicine .6 twice a day and 2g of acetyl-l-carnitine has apparently helped. The progression of my aggressive form of DD stopped with a 20 degree contracture rebound after my second NA procedure about the same time as I started on these medications. Dr. Eaton prescribed the colchicine and I found a study that said ALC helped in Peyronies Disease which is related so I tried it as well. Not sure if one or the other is responsible since I started both at the same time. But in any event, I've had no further contracture in the past 4 months now. And to put it in perspective, in the prior 4 months I had gone from nodule to 45 degrees to 0 degrees after NA #1 to 45 degrees to 0 degrees after NA #2 to 20 degrees. Maybe the disease has stopped on its own but there is no way I'm going to stop taking these drugs and find that out. No side effects are apparent from taking them too. If you actually read up on ALC, it sort of makes sense why it might help as it provides a substance that you lack as the body ages - and DD comes on later in life...who knows. Has anyone else tried this yet???

d'oh. Sorry Steve - you have provided the dose.

Colchicine is a prescription that is normally used for gout...its been around for a long time. Acetyl-L-Carnitine is a nutritional supplement you can buy at good vitamin stores - I use Twinlab or Source Naturals 500mg. I take 2 in the morning before breakfast and 2 before dinner.

I started both at the same time so I don't know if one or both are helping. But the disease progression stopped and aches in my hands and feet stopped shortly thereafter...I have even stopped taking Celebrex which I needed for the aches. Even though I only have one hand fully impacted, the other has cords that formed and the feet had plantar fascitis diagnosed. Both are fine at the moment.

If you take the Acetyl-L-Carnitine by itself, I'd be interested to see if that alone can make a difference for you. I'd love to only take one or the other but won't stop either for fear of the disease resuming its progression which was so aggressive for myself.

I had the most aggressive progression of the disease Dr Eatons seen where he had to operate on me twice over the summer on the same cord and nobody seems to care that after taking these two drugs/supplements the disease has stopped dead in its tracks for 4 months and I have much less aches and pains from it??? unbelievable...

One week ago I started appyling verapimil cream and it seems to be working. I have a fairly large lump in my plam and the cord hasn't gottn bad enough as I can still put my palm flat. The lump has gottne smaller after 1 week and I will continue to apply it twice a day. I'm thinking I might want to try your solution but it might muddy the "experiment".

Ed