I do not have Dupuytren's but the guy I'm dating does and so I've spent a considerable amount of time on the internet trying to learn more about it including browsing extensively through this forum. It seems like there has been very little research done on what nutritional/supplement/topical applications can be used to either slow or reverse progression. (Probably because it's not in any drug development company's best interests to do so). I am curious as to whether any of you have tried working with a dietician, had blood analysis work done, worked with a dermatologist, etc. to develop strategies for managing the situation. Some of the things that are of particular interest to me include: a) xanthine oxidase - an enzyme that is apparently found in high concentrations in the hand tissue of Dupuytren's patients. Most likely source in doing research on that enzyme is homogenzied milk. Has anyone tried switching to non-homogenzied or eliminating milk from the diet? What were your results? b) PABA - have seen some discussion on this site - anyone care to share their experiences? c) DMSO/MSM - jury seems to still be out on this one. Supposedly helps restore a bit of mobility. Since DMSO is a solvent and carries things directly into the system, anyone tried adding essential oils to it or other vitamins when applying to the hands? d) curcumin - it's found in the spice Turmeric and a potent antioxidant - recent research shows it's very promising in cancer treatments. e) topicals and hand care strategies. What seems to help? f) Vitamin C - I've seen some postings that say it seems to agravate the situation. What's your experience? Is that when it's used as a supplement or when it's just acquired through diet?

Any information anyone has on their personal experiences of what works and what doesn't would be appreciated. I am NOT interested in having this topic hijacked to discuss surgery or the collagenese needle study so please limit posts to your experiences with food, vitamins, minerals, enzymes,amino acids and the like and topical solutions.

Over six months I tried a diet with soy instead of cow milk, less meat, and less fat, and also reducing business stress as much as possible. Unfortunately I did not notice any improvement.

But this is only an individual result. Anyway it is difficult to tell whether the nodules' growth would have been faster without this diet.

Wolfgang