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Male DNA link to DC?
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09/29/2009 12:41
Dirv 
09/29/2009 12:41
Dirv 
Male DNA link to DC?

I have both DC and Ledderhose's. Recently I discovered my male Y Haplogroup is R1A1. This is known as the 'Viking' chromosome and I gather, occurs in only about 5% of the population in Britain. A few years ago, the BBC had a programme called 'Blood of the Vikings' in which they were testing people for this chromosome.
I believe that DC is common in people of Nordic and Scots' descent, so wonder if there is a link?

09/29/2009 13:12
newman 
09/29/2009 13:12
newman 

Re: Male DNA link to DC?

Hi Aussie Calling.Morbus Dupuytren is commonly called the Viking Disease to the common man. Regards.

09/30/2009 00:08
flojo 
09/30/2009 00:08
flojo 
Re: Male DNA link to DC?

I am a woman with Dups. Neither of my brothers have it. No one in our family knows of any relative/ancestor who had it. Both parents are of Scottish-Irish heritage. Those ancient Vikings just spread their genes around wherever they conquered or pillaged. I'm wondering if it may be 2 recessive genes that kick in.
Another less usual thing is my thumb is the most involved digit, not my little or ring finger. Mostly though, numerous nodules in my palm caused little contracture and were more easily treated with RT.

09/30/2009 05:35
Dirv 
09/30/2009 05:35
Dirv 
Re: Male DNA link to DC?

I am Scots Irish too on my paternal side. I don't know if there has ever been a study into the DNA link to Dups, or whether one is planned. Most Scots Irish are I gather, R1a1 of R1b.

09/30/2009 06:44
wach 

Administrator

09/30/2009 06:44
wach 

Administrator

Re: Male DNA link to DC?

The Cologne Center for Genomics, Germany, is conducting a research project on Dupuytren's disease and so is the University of Manchester, UK. The relation to the Vikings has been questioned and really, if you look at the geographic distribution in the figure on http://www.dupuytren-online.info/dupuytr...stribution.html, you doubt whether it can be traced back to the Vikings though they might have contributed. Or maybe it has a Celtic component?

Wolfgang

Quote:



I am Scots Irish too on my paternal side. I don't know if there has ever been a study into the DNA link to Dups, or whether one is planned. Most Scots Irish are I gather, R1a1 of R1b.




Edited 09/30/09 09:49

10/01/2009 22:20
MissMyGuitars 
10/01/2009 22:20
MissMyGuitars 
Re: Male DNA link to DC?

Good info Wach !!!

Personally, I have always doubted the Viking heredity link, simply because of the high incidence rate in Japan. I've posted regarding this before. Japan to this day remains one of the most ethnically pure populations on the planet.....

10/01/2009 22:57
flojo 
10/01/2009 22:57
flojo 
Re: Male DNA link to DC?

It was/is such a good story about with the Vikings connection. At least it was something to laugh about.

I'm glad there is now some DNA research related to Dups going on.

10/09/2009 20:04
EKT

not registered

10/09/2009 20:04
EKT

not registered

Re: Male DNA link to DC?

My grandfather, father, and all three uncles all have Dupuytrens. One uncle also has Ledderhose's. I guess we will find out if my brother has it as well soon enough, but obviously there is a genetic trait in my family for this disease. We do have some Scottish heritage, but a lot of others as well.

10/11/2009 14:33
LubaM 
10/11/2009 14:33
LubaM 
Re: Male DNA link to DC?

I am female, jewish, of russian/rumanian/eastern europe ancestry...no Viking/Celtic connections....no one in our family of the older generation has or has had DP...Myself 66, and one of my sisters, 74 have DP and Ledderhose. How many more like me out there??

Luba M.

10/12/2009 01:53
Mike S

not registered

10/12/2009 01:53
Mike S

not registered

Re: Male DNA link to DC?

Similar ancestry and background. Only one in the family with DC. No alcohol. No diabetes. Onset was probably in my late 40's - 57 now.

Then again my wife is half-Swedish. Maybe I got it from her!

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