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Anyone heard of using Proteolytic enzymes ?
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02/25/12 07:19
debrr 
02/25/12 07:19
debrr 
Anyone heard of using Proteolytic enzymes ?

Has anyone have any knowledge about the claims of proteolytic enzymes reducing fibrosis in DD or LD?? Or how about using DMSO (its pain-relieving, collagen-softening, and anti-inflammatory characteristics) in the same?
Has anyone tried anything like this? If so, would you share your impressions/results?
Thank you.

02/25/12 09:25
richardt 
02/25/12 09:25
richardt 
Re: Anyone heard of using Proteolytic enzymes ?

Proteolytic is a adjective used to describe enzymes that chop up proteins. (They cut the amide bonds between the amino acids making up the proteins. These enzymes are also called proteases, or peptidases) Xiaflex is a proteolytic enzyme. Our bodies contain hundreds if not thousands of proteolytic enzymes. Enzymes are large, easily digestible molecules, thus they do not get through unbroken skin, and are readily chopped up by other proteolytic enzymes in our digestive systems. Eating an enzyme pill does nothing as the enzyme is digested by our digestive proteases. Injections are one way to get enymes through our defenses to the place where they can do us some good.

My recent injection of a proteolytic enzyme, xiaflex, left signs of its proteolysis in the thumb webbing of my right hand. The injection site has become a slight depression, about 1 cm in diameter, surrounded by new formed nodules and bands. The targeted band was cut by the enzyme, but another band has grown to take its place. The results of my 3200$ 250 microliter injection 10 months ago were insufficient to justify my using the proteolytic enzyme again.

Good fortune in your efforts to lessen DC's talent for making collagen.

02/25/12 18:02
debrr 
02/25/12 18:02
debrr 
Re: Anyone heard of using Proteolytic enzymes ?

Thank you so much in your thorough response!! Guess my thoughts on taking an oral enzyme are not gonna work.
I am also very sad to hear of your results with injections. Wish there was an easy answer out there!!
Best of luck to you!

02/25/12 20:37
cureall 
02/25/12 20:37
cureall 
Re: Anyone heard of using Proteolytic enzymes ?

I've tried dmso with very little success. It's so hard to know, because for me, this disease seems to hibernate for a while, but then when it's ready, it starts to blossom. If you use DMSO in its hibernation period, you will think that it's working. So it's hard to know if it's the DMSO that's helping or just the way the disease runs.

I wish there was a way to somehow "shrink" collagenese molecules so that they could be passed through the skin.

cureall

02/25/12 20:48
cureall 
02/25/12 20:48
cureall 
Re: Anyone heard of using Proteolytic enzymes ?

speaking of which:


Morphological, qualitative and quantitative analysis of transdermal delivery of drugs and
biologically active molecules by “Transdermal Therapy”
Introduction
Therapeutic agents and biologically active molecules such as peptides, proteins,
oligonucleotides and glycosaminoglycans are characterized by short half-life and low bio-
availability; because of such features the correct administration of such drugs is only by parenteral
injection, usually performed in clinical environment such as the hospital.

Biological and technological research is now studying new and innovative systems for
transdermal drug delivery such as ultrasounds, liposomes, electroporation and iontophoresis; these
techniques are able to increase the transdermal delivery of biologically active molecules. This kind
of transport is therefore thought to easily deliver drugs and molecules with no significant side
effects.

cureall

10/29/12 13:59
stephenjeffrey 
10/29/12 13:59
stephenjeffrey 

Re: Anyone heard of using Proteolytic enzymes ?

richardt:
Our bodies contain hundreds if not thousands of proteolytic enzymes.

Does anyone have any theories as to why these enzymes cannot do their job in the hand/s in terms of controlling the deposition and degradation of collagen in DC sufferers ?

Is it their presence (proteolytic enzymes) in the full thickness grafted tissue as used in Dermofasciectomy that gives the huge difference in long term results for this type of surgery?.

Regards Steve

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collagen-softening   Dermofasciectomy   characteristics   iontophoresis   enzymes   biologically   administration   characterized   anti-inflammatory   glycosaminoglycans   technological   availability   Morphological   pain-relieving   “Transdermal   Proteolytic   molecules   electroporation   transdermal   oligonucleotides