Proteolytic is a adjective used to describe enzymes that chop up proteins. (They cut the amide bonds between the amino acids making up the proteins. These enzymes are also called proteases, or peptidases) Xiaflex is a proteolytic enzyme. Our bodies contain hundreds if not thousands of proteolytic enzymes. Enzymes are large, easily digestible molecules, thus they do not get through unbroken skin, and are readily chopped up by other proteolytic enzymes in our digestive systems. Eating an enzyme pill does nothing as the enzyme is digested by our digestive proteases. Injections are one way to get enymes through our defenses to the place where they can do us some good.

My recent injection of a proteolytic enzyme, xiaflex, left signs of its proteolysis in the thumb webbing of my right hand. The injection site has become a slight depression, about 1 cm in diameter, surrounded by new formed nodules and bands. The targeted band was cut by the enzyme, but another band has grown to take its place. The results of my 3200$ 250 microliter injection 10 months ago were insufficient to justify my using the proteolytic enzyme again.

Good fortune in your efforts to lessen DC's talent for making collagen.

I've tried dmso with very little success. It's so hard to know, because for me, this disease seems to hibernate for a while, but then when it's ready, it starts to blossom. If you use DMSO in its hibernation period, you will think that it's working. So it's hard to know if it's the DMSO that's helping or just the way the disease runs.

I wish there was a way to somehow "shrink" collagenese molecules so that they could be passed through the skin.

cureall

richardt:

---

Our bodies contain hundreds if not thousands of proteolytic enzymes.