I am starting this topic because Joe and John656 had mentioned that they will try Santyl. I think it might make sense to collect experience with Santyl and assess its effect, at least more anecdotes.

For those who are not familiar with Santyl: Abbott Laboratories started marketing Santyl in 2003 (there might have been someone else previously). Santyl is basically collagenase in a topical cream. Abott is using collagenase produced by BioSpecifics (and now probably by Auxilium). The cream also contains ingredients that are meant to help collagenase to get across the skin into the Dupuytren tissue. "This prescription ointment is indicated for debridement of chronic dermal ulcers and second and third degree burns." (http://www.biospace.com/news_story.aspx?...tityId=14254020).

While collagenase injections are aiming to break a cord, Santyl is speculated to be possibly able to reduce a nodule or cord or reduce its growth rate.

So far I haven't found any positive reports on Santyl and Dupuytren's contracture. It might well be that the announcement of Santyl was primarily a marketing effort. But maybe not enough people have tried it. There are also some posts on Santyl in this forum, click on Search, type in Santyl, and select "search in topics and answers".

By the way: We are not encouraging anyone to use Santyl. There is no indication that it works for Dupuytren's contracture and it is not approved by the FDA for this use. But if someone has experience with it, good or bad, it would be great it he/she would post it here.

Wolfgang

Edited at 14.01.08 17:02

Dana,
What strength Santyl are you using and how is applied and how often each day?

While I'm getting RT on my right hand, I'm thinking about trying Santyl on my left hand which is now developing nodules and cords with no contracture. I'm for prevention and early treatment options.

I'm glad this topic was brought up again, because I had not known about it.

Flora

I want to add a post from another thread because it really belongs here:

Quote:

---

Quote:

---

... He knows I have researched this, and Santyl does no harm to healthy tissue -- the only thing that might have happened is nothing. ...
Dana

---

Sorry, but I have difficulties to believe this. How should a chemical be able to distinguish between "healthy" collagen and "sick" Dupuytren's collagen??

We had wonderful reports on topical Verapamil which then turned out as useless. Now it seesm to be Santyl's turn. I don't question Dana's improvements but if Santyl would work so well for everyone I am sure Joe and John would have reported it long ago.

Wolfgang

---

DMSO is not going to carry Santyl into the diseased tissue because neither DMSO nor Santyl "recognize' that tissue as a target in any way. The Santyl is going to go wherever DMSO happens to take it - around, or right through, the bad tissue and possibly right into your blood stream. This sounds dangerous to me.

Gentlemen,

Sorry you believe my post was a fake. I got the original idea from the wonderful data on your site, and thought I would supply back information others might find useful.. In addition to my hands, I have an inorperable tumor on the bottom of one foot ( as I have a clotting disorder they will not remove it) and I now have loose skin there, and for the first time in many years am beginning to see the outline of the side of my foot . I am careful to apply to only the affected areas, and also do not see the difference between injections and my approach. Both cause the eventual release of this medication into the system and the trials have shown no ill effects.

I will not post more t this site due to your attitude toward nonconventional approaches to healing, however I do wish you all well in your wait for a cure.
Dana