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Forum for Dupuytren's and Ledderhose 
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  • Solute Strength & Systemic Signals
    • Solute Strength & Systemic Signals
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    11/12/2011 06:47
    richardt 
    11/12/2011 06:47
    richardt      		Solute Strength & Systemic Signals

    I’ve been pondering. I have aggressive bilateral Dupuytren’s. During the first 20 years or so the condition manifested itself through concurrent development of symmetric contractures. Now after 10 surgical releases, (four on left hand and six on right hand) and 5 grafts, (two on left hand, and three on right) new growths are almost exclusively on my right hand. There is likely a systemic signal molecule(s) that when produced causes collagen fibers to tangle, contract and proliferate. Many biomolecules exert their effects through concentration gradients, the more there is in solution, the greater the effect.

    So… Has anyone in the forum come upon any research into the nature of the biochemical signals that instigate growth of facia? Have any forum members found through research or experience, that the removal/grafting of a particular palmer area is more effective at reducing disease recurrence?

    Time to go stretch my latest stitches.
    11/12/2011 10:31
    wach 

    Administrator
    11/12/2011 10:31
    wach 

    Administrator

    		 Re: Solute Strength & Systemic Signals

    Hi Richard,
    that's still somewhat of a mystery but TGF beta is likely involved. More importantly, an Aussie member of our society, newman, had 20+ surgeries and several skin grafts but the disease still remained aggressive. He then had radiotherapy and that stabilized his condition. He didn't require any more surgeries since then. I believe he had RT about 3-4 years ago.

    You can find his posts by clicking on "search forum" on the left and then search for posts from user newman.

    Wolfgang

    Edited 11/14/11 17:24
    11/14/2011 06:19
    richardt 
    11/14/2011 06:19
    richardt      		Re: Solute Strength & Systemic Signals

    Thanks Wach,

    The TGK beta connection is intriguing and complex. The posts by Newman, informative. I'll be looking into RT next, after bandages come off.

    r
    11/14/2011 15:05
    flojo 
    11/14/2011 15:05
    flojo      		Re: Solute Strength & Systemic Signals

    Very interesting information. Something else to learn about.
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    exclusively   intriguing   biomolecules   connection   Systemic   importantly   proliferate   Dupuytren’s   surgeries   concentration   radiotherapy   aggressive   biochemical   interesting   development   Signals   contractures   Strength   information   informative