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Forum for Dupuytren's and Ledderhose 
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  • DC/DD Brief Information
    • DC/DD Brief Information
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    07/15/2004 23:31
    Imas

    not registered
    07/15/2004 23:31
    Imas

    not registered

    		 DC/DD Brief Information

    Description: Contracture of the palmar fascia due to fibrous proliferation resulting in flexion deformities and loss of function. Similar change may rarely occur in plantar fascia. It usually appears simultaneously.

    Geneties: * Autosomal doiminant with verable penetrance
    * 10 % of patients have a positive family history

    Incidence/Prevalence in USA:

    * Unknown
    * Norway - 9 % males and 3 % females

    Predominant age: 50 for males; 60 for females

    Predominant sex: Male > Female (ranges from 2:1 to 10:1

    Causes: * Unknown
    * Ischemia to the facia with oxygen
    free radical formation
    * Possibly related to release of angiogneic
    basic fibroblast growth factor
    * Related to microhemorrhage and release growth
    factor

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    penetrance   microhemorrhage   doiminant   females   angiogneic   Prevalence   formation   Autosomal   proliferation   Description   Predominant   Incidence   deformities   resulting   Unknown   simultaneously   Contracture   Information   fibroblast   Ischemia