Where can I find help?

NA (needle release)

Collagenase (USA only)


Adresses for doctors providing NA and radiotherapy

What is the Dupuytren Society doing?
A world-wide collaboration of patients and doctors.
The International Dupuytren Society is a non-profit collaboration of patients and physicians to find a cure for this disease and to inform about therapy options.

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Important note:

Material on this web site does not constitute medical advice. It is intended for informational purposes only. Please consult a physician for diagnosis and specific treatment recommendations!

Dupuytren's Contracture and Ledderhose Disease

All you want to know about Dupuytren's contracture and Dupuytren's Disease, including symptoms, support, treatment options, related diseases, research, and links to other resources.

Note: The deadline for submitting papers for the International Dupuytren Award 2024 has been extended to 31 March 2024 dupuytren_award


Dupuytren's Contracture

Dupuytren's Disease (Dupuytren Disease), also called Dupuytren's Contracture or simply Dupuytrens, is a benign thickening of the palm's or finger's connective tissue. Dupuytren Disease is the most crippling hand problem and affecting many people, especially when they get older. Dupuytren Disease typically starts with a tiny nodule in the palm. Eventually cords develop and in progressed stages the affected fingers cannot be fully stretched anymore, thus resulting in what is called "Dupuytren's Contracture". Below picture is showing a very progressed stage of Dupuytren's Contracture. Most patients have much less severe symptoms of Dupuytren Disease and many people with initial symptoms of Dupuytren's will never need any treatment at all. For those who need treatment, a variety of treatments is available, depending on the stage of disease and on the preference of the patients. All these treatments options of Dupuytren disease are explained on this website, including their potential side effects.

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Dupuytren's contracture in very progressed stage:  the ring finger cannot be stretched anymore. In medical language this is called an extension deficit.

Dupuytren's contracture in a very progressed stage:

the left ring finger cannot be stretched anymore.


Ledderhose disease


 Example of Ledderhose disease: a large nodule in the arch of the foot.

Large Ledderhose nodule in the arch of the foot.

Ledderhose disease is similar to Dupuytren's contracture but with nodules developing in the arch of the foot. These nodules can become painful and can in severe cases grow to a size where they affect walking. As for Dupuytren disease, Ledderhose disease typically develops later in life. Patients suffering from Ledderhose disease often eventually also develop symptoms of Dupuytren disease and vice versa. Therapies for Ledderhose's disease are in part similar to those for Dupuytren's contracture but different in detail due to the different functions of hands and feet.

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Please note: a nodule in the hand or bent fingers can have completely other causes than Dupuytren's contracture: other_causes. As each cause requires a different therapy it is extremely important to have the disease properly diagnosed before starting any kind of therapy! The same applies to Ledderhose disease.

In combination with Dupuytren or Ledderhose disease occasionally other, possibly related disease might appear, like knuckle pads (Garrod pads), Frozen shoulder or Peyronie disease. Potential co-morbidities like diabetes, epilepsy or vibration white finger are being researched; see related diseases.

Our Web Site describes evidence based and established treatments, for example hand surgery, but also hew treatment options and results of recent research. Therefore our web site is constantly being updated. It might be worth visiting it frequently!


Other names for Dupuytren's disease

Occasionally Dupuytren's contracture is also called - or occasionally misspelled - Dupuytrens contracture, Dupuytren's constricture, hand constricture, Dupuytren's contractor, dupitrons contracture, Dupeytron's, claw hand, old man's claw hand, crooked finger, lump in palm of hand, contracted finger or simply bent fingers. DUPC is an acronym for Dupuytren's contracture.

In other languages: French:  la Maladie de Dupuytren,  Spanish: enfermeda de Dupuytren, Dutch: de ziekte van Dupuytren and contractuur van Dupuytren, Danish: Kuskefinger, Turkish: Dupuytren Kontraktürü.

French website:

La Maladie de Dupuytren (en Francais)

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All cartoons of this page are by Tiki Küstenmacher, from the book "Mach was, Doc!", Kösel-Verlag, Germany.

© Tiki Küstenmacher, Germany.

The picture of a Dupuytren's contracture was provided by A. Meinel, Dupuytren-Ambulanz, Germany.


Page last modified: 01/07/2021


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