Australia Calling. I noted Gweneth made mention of Radiotherapy and Knuckle Pads. I've had radiotherapy and this has No effct on Knuckle Pads. The Low dose radiotherapy does not penatrate deep into the tissue of the hand so therefore does not reach the other side of the hand. Generally knuckle pads do not cause any trouble. I have tried a creme from Dr Scholls for the use on the hard skin on the feet on the pads. Apply a small amount only to the pad for about a week and I found that the large thick skin tissue could be removed. However the pad will remain. Regards.