No evidence or study data to support using any of the medications listed. I would never use anything on my feet . Have huge nodules on both arches running from toe to heel. No surgery or other procedures used and never will.
My best advice is to wear shoes with soft supporting arches and as long as you have no pressure points on these nodes you will have very little pain. Using mindfulness is essential to daily routines. Have had these on feet and hands for over 30 years. Still moving still going hasn’t stopped me in the least. Adaptation and years of using common sense sustainable aides to take advantage of small milestones daily.

Use as stated in above response a soft insole which means a foam arch only. Cut outs around nodes if needed.
Or contact a specialist who makes foot orthosis which are custom inserts that help align your foot and ankle, aid with position and movement, and can be a preventative step in managing LD. Find a shoe prothesis specialist who works with shoe and arch supports , makes custom fittings for your special needs. These special insole’s made to fit by rx from your doctor will enable you to walk with no pressure on your arches.