Being new to Ledderhose Disease and an AI engineer I created a system to check for the most promising therapies that might come.

The most interesting is a study (in nude rats, so no active immune system, which could be achieved by combination with steroids) that showed that specifics stem cells with PRP can be used to turn overactive myofibroblasts into passive fat cells. Much nicer to step on squishy fat than thick collagen scars...:
https://pubmed.ncbi.nlm.nih.gov/37480917/

This is all science, but a case report just showed the positive effect of PRP alone on a patient in Dupuytren's:
https://athenaeumpub.com/wp-content/uplo...a-Injection.pdf

This makes me wonder if it would be sane for me to to try to find a PRP specialist as I am in early phase Ledderhose before doing Radiotherapy, knowing that it is extremely experimental.

As I also have Peyronie's disease I know that PRP was tested in Peyronie's patients with mixed results as a monotherapy. But one thing that appears to be crucial is timing it in early disease states which is something not really accounted for in most studies as Peyronie's is often treated with "wait and see 1-2 years, then treat with surgery or collagenase".

I think it is time to be hopeful that in 10 years some of these regenerative procedures are more widely tested and hopefully available.

Anyone on the forum who tested PRP?