There has been some discussion about possibly more difficult or complex surgery after radiation. The following is from a 2012 publication by Prof Seegenschmiedt (Dupuytren's Disease and related hyperproliferative disorders, page 364, Springer)

"From this analysis, our advice is
to transfer patients with advanced stages I–IV and/or
recurrent lesions primarily to the hand surgeons. Close
cooperation with hand surgeons is always important,
as prophylactic RT should not impair possible good
surgical results. In our study all those sites, which
required hand surgery due to DD progression after
prophylactic RT in long-term FU, were operated with-
out surgical complications or enhanced perioperative
morbidity."