Clinics providing enzyme injection (collagenase) to treat Dupuytren's contracture

Note that Xiaflex has been approved by the FDA only for use in the United States and only for treatment of Dupuytren's contracture. In Europe the brand name is Xiapex and introduction started in May 2011. Availability schedules may vary due to country specific regulations.

Application of Xiaflex for Peyronie's disease is still under trial. There is no trial for using Xiaflex to treat Ledderhose disease.

Treatment in the USA:

US residents can find doctors/clinics providing Xiaflex on http://www.xiaflex.com/

Treatment in Canada:

Xiaflex was approved for use in Canada on July 9, 2012 and will by marketed by Actelion Pharmaceuticals. The drug is expected to become available in Canada during the first half of 2013.

Treatment in Europe:

Collagenase has been approved by the EU for treating Dupuytren's contracture press_release. To make it available for treatment requires additional national documentations by country which may take several months or even more than a year, depending on country. For the time being it might make sense, irrespective of the country, to clarify to what extent the health insurance is covering the treatment.

If you are suffering from Dupuytren's contracture and are interested in participating in collagenase trials you might register on a special Pfizer web page European_trial_reg. The trial description is on European_trial. In Europe the collagenase product is currently distributed by Pfizer (until April 2013) and named Xiapex.

Pfizer withdrew Xiapex from the German market. This was not for health but for price reasons. A few German clinics are now importing Xiapex from other European countries German-clinics. German insurances are in part reluctant to pay for Xiapex (GKV type insurances).

As we have been contacted about treatment possibilities in the Netherlands and UK specifically, here are a few addresses (sorted alphabetically by town), which already have experience with collagenase.You might also visit the website of the British Dupuytren Society.

The Netherlands:

UMC Groningen
Dept of Plastic Surgery

Prof. Dr. P.M.N. Werker

Hanzeplein 1
9700 RB Groningen

Phone: +31.50.3613220 (for appointments)