Clinics providing enzyme injection (collagenase) to treat Dupuytren's contracture

Note that Xiaflex has been approved by the FDA only for use in the United States and only for treatment of Dupuytren's contracture. In Europe the brand name is Xiapex and introduction started in May 2011. Availability schedules may vary due to country specific regulations.

Application of Xiaflex for Peyronie's disease is still under trial. There is no trial for using Xiaflex to treat Ledderhose disease.

Treatment in the USA:

US residents can find doctors/clinics providing Xiaflex on http://www.xiaflex.com/

Treatment in Europe (European trial):

Collagenase has been approved by the EU for treating Dupuytren's contracture press_release. To make it available for treatment requires additional national documentations by country which may take several months or even more than a year, depending on country. A few clinics in Europe are already engaged in a European trial. For the time being it might make sense, irrespective of the country, to clarify to what extent the health insurance is covering the treatment.

If you are suffering from Dupuytren's contracture and are interested in participating in this trial you might register on a special Pfizer web page European_trial_reg. The trial description is on European_trial. In Europe the collagenase product is distributed by Pfizer and named Xiapex.

As we have been contacted about treatment possibilities in the Netherlands and UK specifically, here are a few addresses (sorted alphabetically by town), which already have experience with collagenase.

The Netherlands:

UMC Groningen
Dept of Plastic Surgery

Prof. Dr. P.M.N. Werker

Hanzeplein 1
9700 RB Groningen

Phone: +31.50.3613220 (for appointments)