Literature on collagenase injection as therapy for Dupuytren's contracture
With permission by ASSH and Elsevier (thank you to both!) we publish the full text of two original papers on the use of collagenase for treatment of Morbus Dupuytren.
Marie Badalamente et al. "Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease" The Journal of Hand Surgery 27A (2002): 788 - 798.
Marie Badalamente and Lawrence Hurst "Efficacy and Safety of Injectable Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture" The Journal of Hand Surgery 32A (2007): 767 - 774.
Lawrence Hurst et al. "Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture" N Engl J Med 361 (2009) p 968-79. This paper includes results of the phase III trial. -- We are awaiting the approval from the publisher to provide the full text on our web site. In the mean time you can buy the article from NEJM or contact the authors or Dupuytren Society for a copy. abstract.
David Gilpin et al. "Injectable Collagenase Clostridium Histolyticum: A New Nonsurgical Treatment for Dupuytren's Disease." J Hand Surg Am 35 (2010): 2027-2038. -- Data from the Australian part of the CORD II trial. abstract. Full paper available from the author or the International Dupuytren Society.
Longer term results and recurrence:
Watt AJ, Curtin CM, and Hentz VR "Collagenase injection as nonsurgical treatment of dupuytren's disease: 8-year follow-up." J Hand Surg Am 35 (2010): 534-539 abstract.
Some news paper articles:
www.nytimes.com/2010/03/16/business/16handbar.html
www.nytimes.com/2010/03/16/business/16hand.html
Page last modified: 01/09/2012