Literature on collagenase injection as therapy for Dupuytren's contracture

With permission by ASSH and Elsevier (thank you to both!) we publish the full text of two original papers on the use of collagenase for treatment of Morbus Dupuytren.

Marie Badalamente et al. "Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease" The Journal of Hand Surgery 27A (2002): 788 - 798.

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Marie Badalamente and Lawrence Hurst "Efficacy and Safety of Injectable Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture" The Journal of Hand Surgery 32A (2007): 767 - 774.

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Lawrence Hurst et al. "Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture" N Engl J Med 361 (2009) p 968-79. This paper includes results of the phase III trial. -- We are awaiting the approval from the publisher to provide the full text on our web site. In the mean time you can buy the article from NEJM or contact the authors or Dupuytren Society for a copy. abstract.

David Gilpin et al. "Injectable Collagenase Clostridium Histolyticum: A New Nonsurgical Treatment for Dupuytren's Disease." J Hand Surg Am 35 (2010): 2027-2038. -- Data from the Australian part of the CORD II trial. abstract. Full paper available from the author or the International Dupuytren Society.

A review of literature has been compiled by TR Lindau, D Armstrong, EA Azzopardi, DE Boyce "Collagenase in Dupuytren’s Disease: A Review of the Literature and Suggested Clinical Use"J CLIN RHEUM MUSC MED 3 (2012):37-46 full_text.

Longer term results and recurrence:

Watt AJ, Curtin CM, and Hentz VR "Collagenase injection as nonsurgical treatment of dupuytren's disease: 8-year follow-up." J Hand Surg Am 35 (2010): 534-539 abstract.

Annet van Rijssen, Hein ter Linden, Paul M. N. Werker "Five-Year Results of a Randomized Clinical Trial on Treatment in Dupuytren’s Disease: Percutaneous Needle Fasciotomy versus Limited Fasciectomy" Plastic Reconstr Surg 129 (2012) p 469–477. abstract In this paper the authors additionally compare with published data on collagenase injection. Full text available from the authors or from the International Dupuytren Society.

A summary of recurrence data is given in the above paper by Lindau et al.. When comparing to needle fasciotomy and sugery the authors cite the above paper paper from van Rijssen et al. but do not adjust the recurrence data as van Rijssen et al. did. Therefore collagenase looks better than the other treatment options.

 

Some news paper articles:

www.nytimes.com/2010/03/16/business/16handbar.html  

www.nytimes.com/2010/03/16/business/16hand.html

 

 

Page last modified: 12/18/2012

 


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