Clinics providing enzyme injection (collagenase) to treat Dupuytren's contracture

Note that Xiaflex has been approved by the FDA only for use in the United States and only for treatment of Dupuytren's contracture. In Europe the brand name is Xiapex and introduction started in May 2011.

NOTE that the manufacturing company Endo has started withdrawing Xiapex/Xiaflex from the European market as well as from Australia and Aisia/Pacific. This seems to be a purely financial decision. Endo is focussing on the more profitable US market, maybe includign Canada. Therefore the below listed clinics in Europe will probably not be able to provid collagenase treatment anymore.


Application of Xiaflex for Peyronie's disease is still under trial. There is no trial for using Xiaflex to treat Ledderhose disease.

Treatment in the USA:

US residents can find doctors/clinics providing Xiaflex on

Treatment in Canada:

Xiaflex has been approved for use in Canada on July 9, 2012, background_info. Interested Canadian patients might also inquire directly with Actelion Pharmaceuticals Canada, 2550 Daniel Johnson Blvd., Laval, Quebec, Canada H7T 2L1, Phone 1-866-531-4885, but we believe Xiaflex is no longer available in Canada.

Treatment in Australia:

As of November 2013 collagenase has been approved in Australia for the treatment of Dupuytren's contracture in adult patients with a palpable cord. The drug is not reimbursed by the government. Interested patients might inquire with Actelion Pharmaceuticals Australia, Phone: +61 2 9486 4600 but we believe the drug is no longer available in Australia.

Treatment in Europe:

Collagenase has been approved by the EU for treating Dupuytren's contracture. In Europe the collagenase product is named Xiapex but has been withdrawn from the European market. This was not for health but for price reasons.




Page last modified: 12/30/2020