Clinics providing enzyme injection (collagenase) to treat Dupuytren's contracture

Note that Xiaflex has been approved by the FDA only for use in the United States and only for treatment of Dupuytren's contracture. In Europe the brand name is Xiapex and introduction started in May 2011.

NOTE that the manufacturing company Endo has started withdrawing Xiapex/Xiaflex from the European market as well as from Australia and Aisia/Pacific. This seems to be a purely financial decision. Endo is focussing on the more profitable US market, maybe includign Canada. Therefore the below listed clinics in Europe will probably not be able to provid collagenase treatment anymore.


Application of Xiaflex for Peyronie's disease is still under trial. There is no trial for using Xiaflex to treat Ledderhose disease.

Treatment in the USA:

US residents can find doctors/clinics providing Xiaflex on

Treatment in Canada:

Xiaflex has been approved for use in Canada on July 9, 2012, background_info. For locating a physician offering collagenase injection you might visit the site (operated by the Canadian distributor Actelion). Interested Canadian patients might also inquire directly with Actelion Pharmaceuticals Canada, 2550 Daniel Johnson Blvd., Laval, Quebec, Canada H7T 2L1, Phone 1-866-531-4885.

We have no information to what extent the Canadian health system will pay for Xiaflex but there seem to be some concerns about pricing cost_effectiveness_Canada.

Treatment in Australia:

As of November 2013 collagenase has been approved in Australia for the treatment of Dupuytren's contracture in adult patients with a palpable cord. The drug is not reimbursed by the government at this stage. More details are on the NPS_website. We don't know which doctors are currently providing this drug. Interested patients might inquire with Actelion Pharmaceuticals Australia, Phone: +61 2 9486 4600.

Treatment in Europe:

Collagenase has been approved by the EU for treating Dupuytren's contracture press_release. To make it available for treatment requires additional national documentations by country which may take several months or even more than a year, depending on country. For the time being it might make sense, irrespective of the country, to clarify to what extent the health insurance is covering the treatment.

In Europe the collagenase product is distributed by Swedish Orphan Biovitrum (Sobi) and named Xiapex. In Germany Xiapex has been withdrawn from the German market effective May 2012. This was not for health but for price reasons. A few German clinics are importing Xiapex from other European countries German-clinics. German health insurances are in part reluctant to pay for Xiapex (specifically GKV type insurances).

As we have been contacted about treatment possibilities in the Netherlands and UK, here are a few addresses having experience with collagenase (sorted alphabetically by town).You might also visit the website of the British Dupuytren's Society.

The Netherlands:

UMC Groningen
Dept of Plastic Surgery

Prof. Dr. P.M.N. Werker

Hanzeplein 1
9700 RB Groningen

Phone: +31.50.3613220 (for appointments)


United Kingdom (see also the clinics listed by the British Dupuytren's Society):

Note that for the time being NICE does not endorse treatment with collagenase (Sept 2015) press_release. Collagenase injection is accepted for restricted use within NHS Scotland and NHS Wales link.

Mr. Mike Hayton

Wrightington Hospital
Hall Lane, Appley Bridge
Wigan WN6 9EP

Phone: (0161) 495 7766

Ms. Ladan Hajipour and Mr. Mike Hayton

The Alexandra Hospital
Mill Lane, Cheadle

Cheshire SK8 2PX

Phone: (0161) 495 7000


Mr. Chris Bainbridge

Pulvertaft Hand Centre

Derbyshire Royal Infirmary

London road


Phone: (01332) 347141


personal: and


Mr. H.J.C.R. Belcher (MS, FRCS)
Queen Victoria Foundation Trust Hospital (NHS)
Holtye Rd

East Grinstead, Sussex RH19 3DZ
Phone: (01342) 414236 (NHS)
Phone: (01342) 851088 (private consulting)


Mr. Mark Broadbent

Nuffield Hospital Glasgow
25 Beaconsfield Road
Glasgow G12 0PJ
Phone: (0141) 334 9441
info /at/

Mr. Henk Giele
Oxford Radcliffe Hospitals and Nuffield Orthopaedic Centre NHS trusts,

Nuffield Manor BMI Oxford and Circle Windsor Hand Clinic Private Hospitals
Oxford and Windsor

Mr. G Shyamalan (Shyam)

West Midlands

Secretary: Alison James 07830774476


Mr. David Warwick

Hand Clinic, Wessex Nuffield Hospital

Southampton, SO53 2DW

Phone: (0845) 4505007


Please refer to our German web site


We will update the release information for Xiapex continously.



Page last modified: 12/13/2019