Literature on collagenase injection as therapy for Dupuytren's contracture

With permission by ASSH and Elsevier (thank you to both!) we publish the full text of two original papers on the use of collagenase for treatment of Morbus Dupuytren.

Marie Badalamente et al. "Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease" The Journal of Hand Surgery 27A (2002): 788 - 798.


Marie Badalamente and Lawrence Hurst "Efficacy and Safety of Injectable Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture" The Journal of Hand Surgery 32A (2007): 767 - 774.


Lawrence Hurst et al. "Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture" N Engl J Med 361 (2009) p 968-79. This paper includes results of the phase III trial full_text.

David Gilpin et al. "Injectable Collagenase Clostridium Histolyticum: A New Nonsurgical Treatment for Dupuytren's Disease." J Hand Surg Am 35 (2010): 2027-2038. -- Data from the Australian part of the CORD II trial. abstract. Full paper available from the author or the International Dupuytren Society.


Longer term results and recurrence:

Clayton A Peimer et al. "Dupuytren Contracture Recurrence Following Treatment with Collagenase Clostridium Histolyticum (CORDLESS Study): 3-Year Data" J Hand Surg Am 38 (2013) p 12-22 abstract and C. Peimer at al. "Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium Histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year Data" JHS 40 (2015): 1597–1605 abstract .

Watt AJ, Curtin CM, and Hentz VR "Collagenase injection as nonsurgical treatment of dupuytren's disease: 8-year follow-up." J Hand Surg Am 35 (2010): 534-539 abstract.

Annet van Rijssen, Hein ter Linden, Paul M. N. Werker "Five-Year Results of a Randomized Clinical Trial on Treatment in Dupuytren’s Disease: Percutaneous Needle Fasciotomy versus Limited Fasciectomy" Plastic Reconstr Surg 129 (2012) p 469–477. abstract In this paper the authors additionally compare with published data on collagenase injection. Full text available from the authors or from the International Dupuytren Society.

A summary of recurrence data is given in the above paper by Lindau et al.. When comparing to needle fasciotomy and surgery the authors cite the above paper paper from van Rijssen et al. but do not adjust the recurrence data as van Rijssen et al. did. Therefore collagenase looks better than the other treatment options.

Some news paper articles:



Page last modified: 09/04/2018